Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women
Inconsistent evidence has been reported on the role of female hormonal factors in the development of lung cancer. This population-based case–control study evaluated the main effect of menstrual/reproductive factors on the risk of lung cancer, and the effect modification by smoking status. Multivaria...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523319301007 |
| _version_ | 1818910997034827776 |
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| author | Kexin Jin Ming Wu Jin-Yi Zhou Jie Yang Ren-Qiang Han Zi-Yi Jin Ai-Min Liu Xiaoping Gu Xiao-Feng Zhang Xu-Shan Wang Ming Su Xu Hu Zheng Sun Gang Li Claire H. Kim Li-Na Mu Na He Jin-Kou Zhao Zuo-Feng Zhang |
| author_facet | Kexin Jin Ming Wu Jin-Yi Zhou Jie Yang Ren-Qiang Han Zi-Yi Jin Ai-Min Liu Xiaoping Gu Xiao-Feng Zhang Xu-Shan Wang Ming Su Xu Hu Zheng Sun Gang Li Claire H. Kim Li-Na Mu Na He Jin-Kou Zhao Zuo-Feng Zhang |
| author_sort | Kexin Jin |
| collection | DOAJ |
| description | Inconsistent evidence has been reported on the role of female hormonal factors in the development of lung cancer. This population-based case–control study evaluated the main effect of menstrual/reproductive factors on the risk of lung cancer, and the effect modification by smoking status. Multivariable unconditional logistic regression models were applied adjusted for age, income, education, county of residence, body mass index, smoking status, pack-years of smoking, and family history of lung cancer. Among 680 lung cancer cases and 1,808 controls, later menopause (at >54 vs. <46 years old) was associated with increased risk of lung cancer (SBOR, semi-Bayes adjusted odds ratio = 1.61, 95% PI, posterior interval = 1.10–2.36). More pregnancies (2 or 3 vs. 0 or 1) was associated with decreased risk (SBOR = 0.71, 95% PI = 0.53, 0.95). Ever being a smoker and having two or fewer pregnancies in one's lifetime could jointly increase the odds of lung cancer (RERI, relative excess risk due to interaction = 1.71, 95% CI = 0.03, 3.38). An increased number of ovulatory cycles was associated with increased risk of lung cancer (SBOR for 13 ovulatory cycles = 1.02, 95% CI = 1.00+, 1.04). |
| first_indexed | 2024-12-19T22:51:41Z |
| format | Article |
| id | doaj.art-d96c0819d5034eeb9e9380ad43f6b030 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-19T22:51:41Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-d96c0819d5034eeb9e9380ad43f6b0302022-12-21T20:02:47ZengElsevierTranslational Oncology1936-52332019-06-01126819827Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese WomenKexin Jin0Ming Wu1Jin-Yi Zhou2Jie Yang3Ren-Qiang Han4Zi-Yi Jin5Ai-Min Liu6Xiaoping Gu7Xiao-Feng Zhang8Xu-Shan Wang9Ming Su10Xu Hu11Zheng Sun12Gang Li13Claire H. Kim14Li-Na Mu15Na He16Jin-Kou Zhao17Zuo-Feng Zhang18Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USADepartment of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaDafeng County Center for Disease Control and Prevention, Dafeng, ChinaDafeng County Center for Disease Control and Prevention, Dafeng, ChinaGanyu County Center for Disease Control and Prevention, Ganyu, ChinaGanyu County Center for Disease Control and Prevention, Ganyu, ChinaChuzhou County Center for Disease Control and Prevention, Chuzhou, ChinaChuzhou County Center for Disease Control and Prevention, Chuzhou, ChinaTongshan County Center for Disease Control and Prevention, Tongshan, ChinaTongshan County Center for Disease Control and Prevention, Tongshan, ChinaDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USADepartment of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USADepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaDepartment of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA; David Geffen School of Medicine, Center for Human Nutrition, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095-1781, USA; Address all correspondence to: Zuo-Feng Zhang, MD, PhD, Department of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, Box 951772, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772.Inconsistent evidence has been reported on the role of female hormonal factors in the development of lung cancer. This population-based case–control study evaluated the main effect of menstrual/reproductive factors on the risk of lung cancer, and the effect modification by smoking status. Multivariable unconditional logistic regression models were applied adjusted for age, income, education, county of residence, body mass index, smoking status, pack-years of smoking, and family history of lung cancer. Among 680 lung cancer cases and 1,808 controls, later menopause (at >54 vs. <46 years old) was associated with increased risk of lung cancer (SBOR, semi-Bayes adjusted odds ratio = 1.61, 95% PI, posterior interval = 1.10–2.36). More pregnancies (2 or 3 vs. 0 or 1) was associated with decreased risk (SBOR = 0.71, 95% PI = 0.53, 0.95). Ever being a smoker and having two or fewer pregnancies in one's lifetime could jointly increase the odds of lung cancer (RERI, relative excess risk due to interaction = 1.71, 95% CI = 0.03, 3.38). An increased number of ovulatory cycles was associated with increased risk of lung cancer (SBOR for 13 ovulatory cycles = 1.02, 95% CI = 1.00+, 1.04).http://www.sciencedirect.com/science/article/pii/S1936523319301007 |
| spellingShingle | Kexin Jin Ming Wu Jin-Yi Zhou Jie Yang Ren-Qiang Han Zi-Yi Jin Ai-Min Liu Xiaoping Gu Xiao-Feng Zhang Xu-Shan Wang Ming Su Xu Hu Zheng Sun Gang Li Claire H. Kim Li-Na Mu Na He Jin-Kou Zhao Zuo-Feng Zhang Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women Translational Oncology |
| title | Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women |
| title_full | Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women |
| title_fullStr | Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women |
| title_full_unstemmed | Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women |
| title_short | Tobacco Smoking Modifies the Association between Hormonal Factors and Lung Cancer Occurrence among Post-Menopausal Chinese Women |
| title_sort | tobacco smoking modifies the association between hormonal factors and lung cancer occurrence among post menopausal chinese women |
| url | http://www.sciencedirect.com/science/article/pii/S1936523319301007 |
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