Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms
OBJECTIVES: Pulmonary involvement in rheumatoid arthritis is directly responsible for 10% to 20% of all mortality. The best way to improve the prognosis is early detection and treatment. The forced oscillation technique is easy to perform and offers a detailed exam, which may be helpful in the early...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2012-09-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000900001 |
| _version_ | 1818522327244079104 |
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| author | Alvaro Camilo Dias Faria Wellington Ribeiro Barbosa Agnaldo José Lopes Geraldo da Rocha Castelar Pinheiro Pedro Lopes de Melo |
| author_facet | Alvaro Camilo Dias Faria Wellington Ribeiro Barbosa Agnaldo José Lopes Geraldo da Rocha Castelar Pinheiro Pedro Lopes de Melo |
| author_sort | Alvaro Camilo Dias Faria |
| collection | DOAJ |
| description | OBJECTIVES: Pulmonary involvement in rheumatoid arthritis is directly responsible for 10% to 20% of all mortality. The best way to improve the prognosis is early detection and treatment. The forced oscillation technique is easy to perform and offers a detailed exam, which may be helpful in the early detection of respiratory changes. This study was undertaken to (1) evaluate the clinical potential of the forced oscillation technique in the detection of early respiratory alterations in rheumatoid arthritis patients with respiratory complaints and (2) to compare the sensitivity of forced oscillation technique and spirometric parameters. METHODS: A total of 40 individuals were analyzed: 20 healthy and 20 with rheumatoid arthritis (90% with respiratory complaints). The clinical usefulness of the parameters was evaluated by investigating the sensibility, the specificity and the area under the receiver operating characteristic curve. ClinicalTrials.gov: NCT01641705. RESULTS: The early adverse respiratory effects of rheumatoid arthritis were adequately detected by the forced oscillation technique parameters, and a high accuracy for clinical use was obtained (AUC.0.9, Se = 80%, Sp = 95%). The use of spirometric parameters did not obtain an appropriate accuracy for clinical use. The diagnostic performance of the forced oscillation technique parameters was significantly higher than that of spirometry. CONCLUSIONS: The results of the present study provide substantial evidence that the forced oscillation technique can contribute to the easy identification of initial respiratory abnormalities in rheumatoid arthritis patients that are not detectable by spirometric exams. Therefore, we believe that the forced oscillation technique can be used as a complementary exam that may help to improve the treatment of breathing disorders in rheumatoid arthritis patients. |
| first_indexed | 2024-12-11T05:31:48Z |
| format | Article |
| id | doaj.art-d96ce75bd6494a2997d5ce6a28f6458e |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T05:31:48Z |
| publishDate | 2012-09-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-d96ce75bd6494a2997d5ce6a28f6458e2022-12-22T01:19:24ZengElsevier EspañaClinics1807-59321980-53222012-09-0167998799410.6061/clinics/2012(09)01Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptomsAlvaro Camilo Dias FariaWellington Ribeiro BarbosaAgnaldo José LopesGeraldo da Rocha Castelar PinheiroPedro Lopes de MeloOBJECTIVES: Pulmonary involvement in rheumatoid arthritis is directly responsible for 10% to 20% of all mortality. The best way to improve the prognosis is early detection and treatment. The forced oscillation technique is easy to perform and offers a detailed exam, which may be helpful in the early detection of respiratory changes. This study was undertaken to (1) evaluate the clinical potential of the forced oscillation technique in the detection of early respiratory alterations in rheumatoid arthritis patients with respiratory complaints and (2) to compare the sensitivity of forced oscillation technique and spirometric parameters. METHODS: A total of 40 individuals were analyzed: 20 healthy and 20 with rheumatoid arthritis (90% with respiratory complaints). The clinical usefulness of the parameters was evaluated by investigating the sensibility, the specificity and the area under the receiver operating characteristic curve. ClinicalTrials.gov: NCT01641705. RESULTS: The early adverse respiratory effects of rheumatoid arthritis were adequately detected by the forced oscillation technique parameters, and a high accuracy for clinical use was obtained (AUC.0.9, Se = 80%, Sp = 95%). The use of spirometric parameters did not obtain an appropriate accuracy for clinical use. The diagnostic performance of the forced oscillation technique parameters was significantly higher than that of spirometry. CONCLUSIONS: The results of the present study provide substantial evidence that the forced oscillation technique can contribute to the easy identification of initial respiratory abnormalities in rheumatoid arthritis patients that are not detectable by spirometric exams. Therefore, we believe that the forced oscillation technique can be used as a complementary exam that may help to improve the treatment of breathing disorders in rheumatoid arthritis patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000900001Rheumatoid ArthritisRespiratory DiseasesForced Oscillation TechniqueEarly DetectionEarly Diagnosis |
| spellingShingle | Alvaro Camilo Dias Faria Wellington Ribeiro Barbosa Agnaldo José Lopes Geraldo da Rocha Castelar Pinheiro Pedro Lopes de Melo Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms Clinics Rheumatoid Arthritis Respiratory Diseases Forced Oscillation Technique Early Detection Early Diagnosis |
| title | Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| title_full | Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| title_fullStr | Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| title_full_unstemmed | Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| title_short | Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| title_sort | contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms |
| topic | Rheumatoid Arthritis Respiratory Diseases Forced Oscillation Technique Early Detection Early Diagnosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000900001 |
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