Orchestrated ensemble activities constitute a hippocampal memory engram
The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10683-2 |
| _version_ | 1818851004191342592 |
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| author | Khaled Ghandour Noriaki Ohkawa Chi Chung Alan Fung Hirotaka Asai Yoshito Saitoh Takashi Takekawa Reiko Okubo-Suzuki Shingo Soya Hirofumi Nishizono Mina Matsuo Makoto Osanai Masaaki Sato Masamichi Ohkura Junichi Nakai Yasunori Hayashi Takeshi Sakurai Takashi Kitamura Tomoki Fukai Kaoru Inokuchi |
| author_facet | Khaled Ghandour Noriaki Ohkawa Chi Chung Alan Fung Hirotaka Asai Yoshito Saitoh Takashi Takekawa Reiko Okubo-Suzuki Shingo Soya Hirofumi Nishizono Mina Matsuo Makoto Osanai Masaaki Sato Masamichi Ohkura Junichi Nakai Yasunori Hayashi Takeshi Sakurai Takashi Kitamura Tomoki Fukai Kaoru Inokuchi |
| author_sort | Khaled Ghandour |
| collection | DOAJ |
| description | The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory. |
| first_indexed | 2024-12-19T06:58:08Z |
| format | Article |
| id | doaj.art-d96ece91fcd34bc6904590181d831291 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T06:58:08Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d96ece91fcd34bc6904590181d8312912022-12-21T20:31:28ZengNature PortfolioNature Communications2041-17232019-06-0110111410.1038/s41467-019-10683-2Orchestrated ensemble activities constitute a hippocampal memory engramKhaled Ghandour0Noriaki Ohkawa1Chi Chung Alan Fung2Hirotaka Asai3Yoshito Saitoh4Takashi Takekawa5Reiko Okubo-Suzuki6Shingo Soya7Hirofumi Nishizono8Mina Matsuo9Makoto Osanai10Masaaki Sato11Masamichi Ohkura12Junichi Nakai13Yasunori Hayashi14Takeshi Sakurai15Takashi Kitamura16Tomoki Fukai17Kaoru Inokuchi18Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaCREST, Japan Science and Technology Agency (JST)Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaCREST, Japan Science and Technology Agency (JST)Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaWPI-IIIS, University of TsukubaCREST, Japan Science and Technology Agency (JST)Life Sciences Research Center, University of ToyamaTohoku University Graduate School of MedicineRIKEN Center for Brain ScienceGraduate School of Sciences and Engineering, Saitama UniversityGraduate School of Sciences and Engineering, Saitama UniversityRIKEN Center for Brain ScienceWPI-IIIS, University of TsukubaDepartment of Psychiatry, University of Texas Southwestern Medical CenterCREST, Japan Science and Technology Agency (JST)Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaThe brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.https://doi.org/10.1038/s41467-019-10683-2 |
| spellingShingle | Khaled Ghandour Noriaki Ohkawa Chi Chung Alan Fung Hirotaka Asai Yoshito Saitoh Takashi Takekawa Reiko Okubo-Suzuki Shingo Soya Hirofumi Nishizono Mina Matsuo Makoto Osanai Masaaki Sato Masamichi Ohkura Junichi Nakai Yasunori Hayashi Takeshi Sakurai Takashi Kitamura Tomoki Fukai Kaoru Inokuchi Orchestrated ensemble activities constitute a hippocampal memory engram Nature Communications |
| title | Orchestrated ensemble activities constitute a hippocampal memory engram |
| title_full | Orchestrated ensemble activities constitute a hippocampal memory engram |
| title_fullStr | Orchestrated ensemble activities constitute a hippocampal memory engram |
| title_full_unstemmed | Orchestrated ensemble activities constitute a hippocampal memory engram |
| title_short | Orchestrated ensemble activities constitute a hippocampal memory engram |
| title_sort | orchestrated ensemble activities constitute a hippocampal memory engram |
| url | https://doi.org/10.1038/s41467-019-10683-2 |
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