Structural Variations of the 3D Genome Architecture in Cervical Cancer Development

Structural Variations of the 3D Genome Architecture in Cervical Cancer Development

Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC) development by inducing structural variations (SVs) in the human genome. SVs are directly associated with the three-dimensional (3D) genome structure leading to cancer development. The detection of SVs is not a t...

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Bibliographic Details
Main Authors: Muhammad Muzammal Adeel, Hao Jiang, Yibeltal Arega, Kai Cao, Da Lin, Canhui Cao, Gang Cao, Peng Wu, Guoliang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cervical cancer
gene expression
Hi-C
SVs
translocation detection
topologically associating domains
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.706375/full

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