Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval.
The association between the disease-free interval (DFI) and survival after a locoregional recurrence (LRR) or second primary (SP) breast cancer remains uncertain. The objective of this study is to clarify this association to obtain more information on expected prognosis. Women first diagnosed with e...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4393268?pdf=render |
| _version_ | 1818997732538318848 |
|---|---|
| author | Annemieke Witteveen Annemiek B G Kwast Gabe S Sonke Maarten J IJzerman Sabine Siesling |
| author_facet | Annemieke Witteveen Annemiek B G Kwast Gabe S Sonke Maarten J IJzerman Sabine Siesling |
| author_sort | Annemieke Witteveen |
| collection | DOAJ |
| description | The association between the disease-free interval (DFI) and survival after a locoregional recurrence (LRR) or second primary (SP) breast cancer remains uncertain. The objective of this study is to clarify this association to obtain more information on expected prognosis. Women first diagnosed with early breast cancer between 2003-2006 were selected from the Netherlands Cancer Registry. LRRs and SP tumours within five years of first diagnosis were examined. The five-year period was subsequently divided into three equal intervals. Prognostic significance of the DFI on survival after a LRR or SP tumour was determined using Kaplan-Meier estimates and multivariable Cox regression analysis. Follow-up was complete until January 1, 2014. A total of 37,278 women was included in the analysis. LRRs or SP tumours were diagnosed in 890 (2,4%) and 897 (2,4%) respectively. Longer DFI was strongly and independently related to an improved survival after a LRR (long versus short: HR 0.65, 95% CI 0.48-0.88; medium versus short HR 0.81, 95% CI 0.65-1.01). Other factors related to improved survival after LRR were younger age (<70 years) and surgical removal of the recurrence. No significant association was found between DFI and survival after SP tumours. This is the first study to explore the association between the DFI and survival after recurrence in a nationwide population-based cancer registry. The DFI before a LRR is an independent prognostic factor for survival, with a longer DFI predicting better prognosis. |
| first_indexed | 2024-12-20T21:50:19Z |
| format | Article |
| id | doaj.art-d973e2baf6a945a4a3dd84a09a57ca0f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T21:50:19Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d973e2baf6a945a4a3dd84a09a57ca0f2022-12-21T19:25:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012083210.1371/journal.pone.0120832Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval.Annemieke WitteveenAnnemiek B G KwastGabe S SonkeMaarten J IJzermanSabine SieslingThe association between the disease-free interval (DFI) and survival after a locoregional recurrence (LRR) or second primary (SP) breast cancer remains uncertain. The objective of this study is to clarify this association to obtain more information on expected prognosis. Women first diagnosed with early breast cancer between 2003-2006 were selected from the Netherlands Cancer Registry. LRRs and SP tumours within five years of first diagnosis were examined. The five-year period was subsequently divided into three equal intervals. Prognostic significance of the DFI on survival after a LRR or SP tumour was determined using Kaplan-Meier estimates and multivariable Cox regression analysis. Follow-up was complete until January 1, 2014. A total of 37,278 women was included in the analysis. LRRs or SP tumours were diagnosed in 890 (2,4%) and 897 (2,4%) respectively. Longer DFI was strongly and independently related to an improved survival after a LRR (long versus short: HR 0.65, 95% CI 0.48-0.88; medium versus short HR 0.81, 95% CI 0.65-1.01). Other factors related to improved survival after LRR were younger age (<70 years) and surgical removal of the recurrence. No significant association was found between DFI and survival after SP tumours. This is the first study to explore the association between the DFI and survival after recurrence in a nationwide population-based cancer registry. The DFI before a LRR is an independent prognostic factor for survival, with a longer DFI predicting better prognosis.http://europepmc.org/articles/PMC4393268?pdf=render |
| spellingShingle | Annemieke Witteveen Annemiek B G Kwast Gabe S Sonke Maarten J IJzerman Sabine Siesling Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. PLoS ONE |
| title | Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. |
| title_full | Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. |
| title_fullStr | Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. |
| title_full_unstemmed | Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. |
| title_short | Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. |
| title_sort | survival after locoregional recurrence or second primary breast cancer impact of the disease free interval |
| url | http://europepmc.org/articles/PMC4393268?pdf=render |
| work_keys_str_mv | AT annemiekewitteveen survivalafterlocoregionalrecurrenceorsecondprimarybreastcancerimpactofthediseasefreeinterval AT annemiekbgkwast survivalafterlocoregionalrecurrenceorsecondprimarybreastcancerimpactofthediseasefreeinterval AT gabessonke survivalafterlocoregionalrecurrenceorsecondprimarybreastcancerimpactofthediseasefreeinterval AT maartenjijzerman survivalafterlocoregionalrecurrenceorsecondprimarybreastcancerimpactofthediseasefreeinterval AT sabinesiesling survivalafterlocoregionalrecurrenceorsecondprimarybreastcancerimpactofthediseasefreeinterval |