In vivo Infection Dynamics and Human Adaptive Changes of SIVsm-Derived Viral Siblings SIVmac239, SIVB670, and SIVhu in Humanized Mice as a Paralog of HIV-2 Genesis

In vivo Infection Dynamics and Human Adaptive Changes of SIVsm-Derived Viral Siblings SIVmac239, SIVB670, and SIVhu in Humanized Mice as a Paralog of HIV-2 Genesis

Simian immunodeficiency virus native to sooty mangabeys (SIVsm) is believed to have given rise to HIV-2 through cross-species transmission and evolution in the human. SIVmac239 and SIVB670, pathogenic to macaques, and SIVhu, isolated from an accidental human infection, also have origins in SIVsm. Wi...

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Bibliographic Details
Main Authors: James Z. Curlin, Kimberly Schmitt, Leila Remling-Mulder, Ryan V. Moriarty, John J. Baczenas, Kelly Goff, Shelby O'Connor, Mark Stenglein, Preston A. Marx, Ramesh Akkina
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Virology
Subjects:
HIV origins and evolution from SIV
SIV cross-species transmission
a dual purpose humanized mouse model for HIV and SIV research
SIVmac and SIVB670 pathogenesis and evolution in humanized mice
viral adaptive changes and evolution
SIV evolution into HIV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2021.813606/full

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