Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep
Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defined as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3’...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-05-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2792.pdf |
| _version_ | 1827849422361329664 |
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| author | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN |
| author_facet | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN |
| author_sort | Jianlei JIA |
| collection | DOAJ |
| description | Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defined as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3’-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103 Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identifi ed, which were G1339A and
A1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354G variant of the 3’UTR region, that AA and A were the preponderant genotype and allele, respectively. The χ2 independence test analyses indicated that the A1354G variant of BMPR-1B gene 3’UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P<0.05). These results demonstrate that the BMPR-1B gene 3’-UTR region might be a potential candidate gene for marker-assisted selection (MAS). |
| first_indexed | 2024-03-12T10:03:51Z |
| format | Article |
| id | doaj.art-d9769962d3844a45a0f97a7cf55a65a1 |
| institution | Directory Open Access Journal |
| issn | 1300-6045 1309-2251 |
| language | English |
| last_indexed | 2024-03-12T10:03:51Z |
| publishDate | 2021-05-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-d9769962d3844a45a0f97a7cf55a65a12023-09-02T11:26:27ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1300-60451309-22512021-05-0127328528910.9775/kvfd.2021.25064Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan SheepJianlei JIA0https://orcid.org/0000-0001-5843-1709Dejuan XIE1https://orcid.org/0000-0002-6204-8486Yingying ZHANG2https://orcid.org/0000-0002-5022-7233 Huaixia ZHANG3https://orcid.org/0000-0003-1987-6777Liping ZHANG4https://orcid.org/0000-0001-8365-3530 Shengzhen HOU5https://orcid.org/0000-0001-2345-6789 Qian CHEN6https://orcid.org/0000-0002-5523-3659 College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINA College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINA College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINABone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defined as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3’-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103 Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identifi ed, which were G1339A and A1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354G variant of the 3’UTR region, that AA and A were the preponderant genotype and allele, respectively. The χ2 independence test analyses indicated that the A1354G variant of BMPR-1B gene 3’UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P<0.05). These results demonstrate that the BMPR-1B gene 3’-UTR region might be a potential candidate gene for marker-assisted selection (MAS).http://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2792.pdftibetan sheepbmpr-1b gene3’-utr regionpolymorphismlitter size |
| spellingShingle | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep Kafkas Universitesi Veteriner Fakültesi Dergisi tibetan sheep bmpr-1b gene 3’-utr region polymorphism litter size |
| title | Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep |
| title_full | Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep |
| title_fullStr | Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep |
| title_full_unstemmed | Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep |
| title_short | Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep |
| title_sort | association of bmpr 1b gene 3 utr region polymorphism with litter size in tibetan sheep |
| topic | tibetan sheep bmpr-1b gene 3’-utr region polymorphism litter size |
| url | http://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2792.pdf |
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