Architectures and complex functions of tandem riboswitches

Architectures and complex functions of tandem riboswitches

Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer domain result in ordinary dose-response curves that require approximately a 100-fold change in ligand concentration to cover nearly the full dynamic range for gene regulation. However, by using multiple ribo...

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Bibliographic Details
Main Authors: Madeline E. Sherlock, Gadareth Higgs, Diane Yu, Danielle L. Widner, Neil A. White, Narasimhan Sudarsan, Harini Sadeeshkumar, Kevin R. Perkins, Gayan Mirihana Arachchilage, Sarah N. Malkowski, Christopher G. King, Kimberly A. Harris, Glenn Gaffield, Ruben M. Atilho, Ronald R. Breaker
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:RNA Biology
Subjects:
aptamer
noncoding rna
gene regulation
logic gate
transcription control
translation control
Online Access:http://dx.doi.org/10.1080/15476286.2022.2119017

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