Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
BACKGROUND: The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections. METHODOLOGY: In this work, a small-molecule inhibitor of the WNV NS3pro has been identified b...
| Автори: | , , , , , , , , , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Public Library of Science (PLoS)
2009-01-01
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| Серія: | PLoS Neglected Tropical Diseases |
| Онлайн доступ: | http://europepmc.org/articles/PMC2613028?pdf=render |