Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

Summary: The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact in vivo is controversial. Here, we show that deletion of vpr is associated with...

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Bibliographic Details
Main Authors: Alexandre Laliberté, Caterina Prelli Bozzo, Christiane Stahl-Hennig, Victoria Hunszinger, Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Gregory K. Tharp, Dietmar Fuchs, Prachi Mehrotra Gupta, Guido Silvestri, Sydney A. Nelson, Laura Parodi, Luis Giavedoni, Steven E. Bosinger, Konstantin M.J. Sparrer, Frank Kirchhoff
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Immunology
Immunity
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223024288

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