Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
Purpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to iden...
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MDPI AG
2023-10-01
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Online Access: | https://www.mdpi.com/2077-0383/12/20/6547 |
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author | Shun Liu Mingxian Chen Liang Tang Xuping Li Shenghua Zhou |
author_facet | Shun Liu Mingxian Chen Liang Tang Xuping Li Shenghua Zhou |
author_sort | Shun Liu |
collection | DOAJ |
description | Purpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to identify a cohort of ischemic heart disease patients who underwent serum ferritin testing. We conducted regression analyses, employed the overlap propensity score weighting model, and utilized the restricted cubic splines model to comprehensively investigate the associations between serum ferritin levels and clinical outcomes. Results: Our cohort included 1173 patients with diagnosed ischemic heart disease, categorized into high and low serum ferritin groups. After meticulous adjustment for confounding factors in a fully adjusted model, the hazard ratios (HRs) for 90-day and 1-year mortality were 1.63 (95% CI: 1.27–2.09) and 1.49 (95% CI: 1.19–1.86), respectively, in the high-ferritin group compared to the low-ferritin group. Subsequent analyses with propensity score weighting confirmed these results. Remarkably, restricted cubic spline analysis revealed an almost linear relationship between log-transformed serum ferritin levels and the risk of both 90-day and 1-year all-cause mortality. Moreover, incorporating ferritin into conventional severity of illness scores significantly improved the area under the curve for both 90-day and 1-year mortality. Conclusions: This study provides compelling evidence regarding the prognostic significance of serum ferritin in predicting 90-day and one-year mortality rates among patients diagnosed with ischemic heart disease. |
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issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T21:10:17Z |
publishDate | 2023-10-01 |
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spelling | doaj.art-d97b1aea6e55442f9a957c64b2f56b392023-11-19T16:52:37ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011220654710.3390/jcm12206547Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care UnitsShun Liu0Mingxian Chen1Liang Tang2Xuping Li3Shenghua Zhou4Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaPurpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to identify a cohort of ischemic heart disease patients who underwent serum ferritin testing. We conducted regression analyses, employed the overlap propensity score weighting model, and utilized the restricted cubic splines model to comprehensively investigate the associations between serum ferritin levels and clinical outcomes. Results: Our cohort included 1173 patients with diagnosed ischemic heart disease, categorized into high and low serum ferritin groups. After meticulous adjustment for confounding factors in a fully adjusted model, the hazard ratios (HRs) for 90-day and 1-year mortality were 1.63 (95% CI: 1.27–2.09) and 1.49 (95% CI: 1.19–1.86), respectively, in the high-ferritin group compared to the low-ferritin group. Subsequent analyses with propensity score weighting confirmed these results. Remarkably, restricted cubic spline analysis revealed an almost linear relationship between log-transformed serum ferritin levels and the risk of both 90-day and 1-year all-cause mortality. Moreover, incorporating ferritin into conventional severity of illness scores significantly improved the area under the curve for both 90-day and 1-year mortality. Conclusions: This study provides compelling evidence regarding the prognostic significance of serum ferritin in predicting 90-day and one-year mortality rates among patients diagnosed with ischemic heart disease.https://www.mdpi.com/2077-0383/12/20/6547markerprognosisferritinischemic heart diseaseMIMIC-IV database |
spellingShingle | Shun Liu Mingxian Chen Liang Tang Xuping Li Shenghua Zhou Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units Journal of Clinical Medicine marker prognosis ferritin ischemic heart disease MIMIC-IV database |
title | Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units |
title_full | Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units |
title_fullStr | Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units |
title_full_unstemmed | Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units |
title_short | Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units |
title_sort | association between serum ferritin and prognosis in patients with ischemic heart disease in intensive care units |
topic | marker prognosis ferritin ischemic heart disease MIMIC-IV database |
url | https://www.mdpi.com/2077-0383/12/20/6547 |
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