Interactive Effect of Aerobic Training and L-Carnitine Supplementation on Cardiac Tissue Apelin and Insulin Resistance in Diabetic Rats
Background: Adipokine apelin plays an important role in regulating energy homeostasis and improving insulin resistance. The purpose of this study was to investigate the interactive effect of aerobic exercise and L-carnitine supplementation on serum levels of cardiac tissue apelin and insulin resista...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2020-02-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/12366 |
| Summary: | Background: Adipokine apelin plays an important role in regulating energy homeostasis and improving insulin resistance. The purpose of this study was to investigate the interactive effect of aerobic exercise and L-carnitine supplementation on serum levels of cardiac tissue apelin and insulin resistance in diabetic rats.
Methods: In this experimental study, 40 male rats were randomly divided into five groups of healthy control, diabetic control (placebo), diabetes + L-carnitine, diabetes + aerobic exercise, and diabetes + L-carnitine + exercise. After induction of diabetes in rats, aerobic exercise and L-carnitine supplementation were performed for six weeks and five sessions per week. Aerobic training in the active groups consisted of 10 minutes of treadmill exercise with 60% of maximal oxygen uptake, which increased by 20 minutes from the third week, with no control group training.
Findings: There was a significant increase in apelin in the diabetes + aerobic training group and the diabetes + aerobic training + L-carnitine group compared to the control and placebo groups (P = 0.001). There was no significant difference between the two active groups (P = 0.227). There was a significant decrease in insulin and glucose levels in the active groups compared to the control and placebo groups, too (P = 0.001).
Conclusion: Aerobic training and consumption of L-carnitine can increase cardiac tissue apelin and decrease insulin resistance. |
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| ISSN: | 1027-7595 1735-854X |