Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance
Diabetic retinopathy(DR), one of the common complications of diabetes, is a major cause of blindness. Traditionally, DR has been considered primarily a microvascular disease, and as research has progressed, it is now believed that disruption of the neuro-glia-vascular unit(NVU)and imbalance in its c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-08-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/8/202208014.pdf |
| _version_ | 1811311570756567040 |
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| author | Bao-Hua Li Chao-Hong Guo Cheng-Wei Guo |
| author_facet | Bao-Hua Li Chao-Hong Guo Cheng-Wei Guo |
| author_sort | Bao-Hua Li |
| collection | DOAJ |
| description | Diabetic retinopathy(DR), one of the common complications of diabetes, is a major cause of blindness. Traditionally, DR has been considered primarily a microvascular disease, and as research has progressed, it is now believed that disruption of the neuro-glia-vascular unit(NVU)and imbalance in its coupling mechanisms(coupling)play a key role in the early onset of DR. Understanding the cellular and molecular basis of NVU and how diabetes alters normal cellular communication and disrupts the cellular environment is important for the early prevention and treatment of DR. This paper summarizes the retinal NVU and its involvement in the molecular mechanism of DR pathogenesis, DR treatment based on retinal NVU repair, and discusses the future prospects and problems of DR. |
| first_indexed | 2024-04-13T10:20:07Z |
| format | Article |
| id | doaj.art-d97c8c4ab2ea4159a32575d44de56b81 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-13T10:20:07Z |
| publishDate | 2022-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-d97c8c4ab2ea4159a32575d44de56b812022-12-22T02:50:32ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-08-012281309131210.3980/j.issn.1672-5123.2022.8.14202208014Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalanceBao-Hua Li0Chao-Hong Guo1Cheng-Wei Guo2Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, ChinaShandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, ChinaDiabetic retinopathy(DR), one of the common complications of diabetes, is a major cause of blindness. Traditionally, DR has been considered primarily a microvascular disease, and as research has progressed, it is now believed that disruption of the neuro-glia-vascular unit(NVU)and imbalance in its coupling mechanisms(coupling)play a key role in the early onset of DR. Understanding the cellular and molecular basis of NVU and how diabetes alters normal cellular communication and disrupts the cellular environment is important for the early prevention and treatment of DR. This paper summarizes the retinal NVU and its involvement in the molecular mechanism of DR pathogenesis, DR treatment based on retinal NVU repair, and discusses the future prospects and problems of DR.http://ies.ijo.cn/cn_publish/2022/8/202208014.pdfretinal neurovascular unitdiabetic retinopathycoupling mechanismresearch progress |
| spellingShingle | Bao-Hua Li Chao-Hong Guo Cheng-Wei Guo Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance Guoji Yanke Zazhi retinal neurovascular unit diabetic retinopathy coupling mechanism research progress |
| title | Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| title_full | Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| title_fullStr | Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| title_full_unstemmed | Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| title_short | Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| title_sort | research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance |
| topic | retinal neurovascular unit diabetic retinopathy coupling mechanism research progress |
| url | http://ies.ijo.cn/cn_publish/2022/8/202208014.pdf |
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