A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations
The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs). These DHPMs (synthetic and natural) possess a wide range of pharmacological activities. A simple, eff...
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| Format: | Article |
| Language: | English |
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Salahaddin University-Erbil
2023-08-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
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| Online Access: | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/714 |
| _version_ | 1797347715585146880 |
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| author | Rostam R. Braiem |
| author_facet | Rostam R. Braiem |
| author_sort | Rostam R. Braiem |
| collection | DOAJ |
| description | The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs). These DHPMs (synthetic and natural) possess a wide range of pharmacological activities. A simple, efficient, and cost-effective method for the synthesis of 3,4-dihydropyrimidin-2(1H)-one by a one-pot three-component cyclocondensation reaction of a 1,3-dicarbonyl compound, an aldehyde and urea using HCl as catalyst is reported. The three-component condensation of an aldehyde, a -keto ester and urea in the presence of a catalytic amount of HCl, 3,4-Dihydropyrimidin-2(1H)-ones were synthesized in high yields. Recently much attention has been devoted towards dihydropyrimidine derivatives due to their significant therapeutic and medicinal properties. All the products in reaction obtained in good to very good yields by proceeding through a simple and efficient procedure. All the synthesized compound’s structure has been established by advanced spectroscopic data (FTIR, 1HNMR, and 13CNMR) and evaluated for their antibacterial activity against two types of bacteria (S. aureus and E.coli). |
| first_indexed | 2024-03-08T11:51:48Z |
| format | Article |
| id | doaj.art-d97cd425182b467e915f39fa2b2c777f |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2024-03-08T11:51:48Z |
| publishDate | 2023-08-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-d97cd425182b467e915f39fa2b2c777f2024-01-24T09:12:40ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862023-08-0135410.21271/ZJPAS.35.4.15A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli CondensationsRostam R. BraiemThe Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs). These DHPMs (synthetic and natural) possess a wide range of pharmacological activities. A simple, efficient, and cost-effective method for the synthesis of 3,4-dihydropyrimidin-2(1H)-one by a one-pot three-component cyclocondensation reaction of a 1,3-dicarbonyl compound, an aldehyde and urea using HCl as catalyst is reported. The three-component condensation of an aldehyde, a -keto ester and urea in the presence of a catalytic amount of HCl, 3,4-Dihydropyrimidin-2(1H)-ones were synthesized in high yields. Recently much attention has been devoted towards dihydropyrimidine derivatives due to their significant therapeutic and medicinal properties. All the products in reaction obtained in good to very good yields by proceeding through a simple and efficient procedure. All the synthesized compound’s structure has been established by advanced spectroscopic data (FTIR, 1HNMR, and 13CNMR) and evaluated for their antibacterial activity against two types of bacteria (S. aureus and E.coli).https://zancojournal.su.edu.krd/index.php/JPAS/article/view/714dihydropyrimidinonemulticomponent reactionbiginelli-condensationacid-catalyzed reactionsantibacterial activity |
| spellingShingle | Rostam R. Braiem A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations Zanco Journal of Pure and Applied Sciences dihydropyrimidinone multicomponent reaction biginelli-condensation acid-catalyzed reactions antibacterial activity |
| title | A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations |
| title_full | A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations |
| title_fullStr | A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations |
| title_full_unstemmed | A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations |
| title_short | A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations |
| title_sort | one pot multi component synthesis of some new dihydropyrimidine derivatives via biginelli condensations |
| topic | dihydropyrimidinone multicomponent reaction biginelli-condensation acid-catalyzed reactions antibacterial activity |
| url | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/714 |
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