Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers
With the increased interest in information on gut microbes, people are realizing the benefits of probiotics to health, and new technologies to improve the viability of probiotics are still explored. However, most probiotics have poor resistance to adverse environments. In order to improve the viabil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/7/1565 |
| _version_ | 1797562430991106048 |
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| author | Hongliang Yu Weihua Liu Dongmei Li Chunhong Liu Zhibiao Feng Bin Jiang |
| author_facet | Hongliang Yu Weihua Liu Dongmei Li Chunhong Liu Zhibiao Feng Bin Jiang |
| author_sort | Hongliang Yu |
| collection | DOAJ |
| description | With the increased interest in information on gut microbes, people are realizing the benefits of probiotics to health, and new technologies to improve the viability of probiotics are still explored. However, most probiotics have poor resistance to adverse environments. In order to improve the viability of lactic acid bacteria, polylactic acid (PLA) nanofibers were prepared by coaxial electrospinning. The electrospinning voltage was 16 kV, and the distance between spinneret and collector was 15 cm. The feed rates of the shell and core solutions were 1.0 and 0.25 mL/h, respectively. The lactic acid bacteria were encapsulated in the coaxial electrospun nanofibers with PLA and fructooligosaccharides (FOS) as the shell materials. Scanning electron microscopy, transmission electron microscopy, and laser scanning confocal microscopy showed that lactic acid bacteria were encapsulated in the coaxial electrospun nanofibers successfully. The water contact angle test indicated that coaxial electrospun nanofiber films had good hydrophobicity. An in vitro simulated digestion test exhibited that the survival rate of lactic acid bacteria encapsulated in coaxial electrospun nanofiber films was more than 72%. This study proved that the viability of probiotics can be improved through encapsulation within coaxial electrospun PLA nanofibers and provided a novel approach for encapsulating bioactive substances. |
| first_indexed | 2024-03-10T18:29:06Z |
| format | Article |
| id | doaj.art-d97f10a9da6b4620984dc232df08bd3e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T18:29:06Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-d97f10a9da6b4620984dc232df08bd3e2023-11-20T06:48:51ZengMDPI AGPolymers2073-43602020-07-01127156510.3390/polym12071565Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun NanofibersHongliang Yu0Weihua Liu1Dongmei Li2Chunhong Liu3Zhibiao Feng4Bin Jiang5Department of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaDepartment of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaDepartment of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaDepartment of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaDepartment of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaDepartment of Applied Chemistry, Northeast Agricultural University, Harbin 150000, ChinaWith the increased interest in information on gut microbes, people are realizing the benefits of probiotics to health, and new technologies to improve the viability of probiotics are still explored. However, most probiotics have poor resistance to adverse environments. In order to improve the viability of lactic acid bacteria, polylactic acid (PLA) nanofibers were prepared by coaxial electrospinning. The electrospinning voltage was 16 kV, and the distance between spinneret and collector was 15 cm. The feed rates of the shell and core solutions were 1.0 and 0.25 mL/h, respectively. The lactic acid bacteria were encapsulated in the coaxial electrospun nanofibers with PLA and fructooligosaccharides (FOS) as the shell materials. Scanning electron microscopy, transmission electron microscopy, and laser scanning confocal microscopy showed that lactic acid bacteria were encapsulated in the coaxial electrospun nanofibers successfully. The water contact angle test indicated that coaxial electrospun nanofiber films had good hydrophobicity. An in vitro simulated digestion test exhibited that the survival rate of lactic acid bacteria encapsulated in coaxial electrospun nanofiber films was more than 72%. This study proved that the viability of probiotics can be improved through encapsulation within coaxial electrospun PLA nanofibers and provided a novel approach for encapsulating bioactive substances.https://www.mdpi.com/2073-4360/12/7/1565coaxial electrospinningpolylactic acidprobioticsnanofibers |
| spellingShingle | Hongliang Yu Weihua Liu Dongmei Li Chunhong Liu Zhibiao Feng Bin Jiang Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers Polymers coaxial electrospinning polylactic acid probiotics nanofibers |
| title | Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers |
| title_full | Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers |
| title_fullStr | Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers |
| title_full_unstemmed | Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers |
| title_short | Targeting Delivery System for <i>Lactobacillus Plantarum</i> Based on Functionalized Electrospun Nanofibers |
| title_sort | targeting delivery system for i lactobacillus plantarum i based on functionalized electrospun nanofibers |
| topic | coaxial electrospinning polylactic acid probiotics nanofibers |
| url | https://www.mdpi.com/2073-4360/12/7/1565 |
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