Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity
As the obesity epidemic continues to grow inexorably worldwide, the need to develop effective strategies to prevent and control obesity seems crucial. The use of molecular tools can be useful to characterize different obesity phenotypes to provide more precise nutritional recommendations. This study...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/1/43 |
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| author | Iker Jauregibeitia Kevin Portune Sonia Gaztambide Itxaso Rica Itziar Tueros Olaia Velasco Gema Grau Alicia Martín Luis Castaño Anna Vita Larocca Federica Di Nolfo Carla Ferreri Sara Arranz |
| author_facet | Iker Jauregibeitia Kevin Portune Sonia Gaztambide Itxaso Rica Itziar Tueros Olaia Velasco Gema Grau Alicia Martín Luis Castaño Anna Vita Larocca Federica Di Nolfo Carla Ferreri Sara Arranz |
| author_sort | Iker Jauregibeitia |
| collection | DOAJ |
| description | As the obesity epidemic continues to grow inexorably worldwide, the need to develop effective strategies to prevent and control obesity seems crucial. The use of molecular tools can be useful to characterize different obesity phenotypes to provide more precise nutritional recommendations. This study aimed to determine the fatty acid (FA) profile of red blood cell (RBC) membranes, together with the evaluation of their dietary intake and biochemical parameters, of children and adults with obesity. An observational study was carried out on 196 children (113 with normal weight and 83 with obesity) and 91 adults (30 with normal weight and 61 with obesity). Mature RBC membrane phospholipids were analyzed for FA composition by gas chromatography-mass spectrometry (GC-MS). Dietary habits were evaluated using validated food frequency questionnaires (FFQ). Children with obesity presented higher levels of ω-6 polyunsaturated FAs (mainly linoleic acid, <i>p</i> = 0.01) and lower values of ω-3 FAs (mainly DHA, <i>p</i> < 0.001) compared with adults. Regarding blood biochemical parameters, children with obesity presented lower levels of glucose, LDL cholesterol, and alanine aminotransferase compared with adults with obesity. These lipidomic differences could be considered to provide specific nutritional recommendations for different age groups, based on an adequate fat intake. |
| first_indexed | 2024-03-09T05:30:44Z |
| format | Article |
| id | doaj.art-d97fa600b7584600a3dc545f598265f5 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T05:30:44Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-d97fa600b7584600a3dc545f598265f52023-12-03T12:32:52ZengMDPI AGMetabolites2218-19892021-01-011114310.3390/metabo11010043Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with ObesityIker Jauregibeitia0Kevin Portune1Sonia Gaztambide2Itxaso Rica3Itziar Tueros4Olaia Velasco5Gema Grau6Alicia Martín7Luis Castaño8Anna Vita Larocca9Federica Di Nolfo10Carla Ferreri11Sara Arranz12AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio–Bizkaia, SpainAZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio–Bizkaia, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainAZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio–Bizkaia, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERDEM/CIBERER, UPV/EHU, Endo–ERN, 48903 Barakaldo, SpainLipidomic Laboratory, Lipinutragen srl, Via di Corticella 181/4, 40128 Bologna, ItalyLipidomic Laboratory, Lipinutragen srl, Via di Corticella 181/4, 40128 Bologna, ItalyConsiglio Nazionale delle Ricerche, ISOF, Via Piero Gobetti 101, 40129 Bologna, ItalyAZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio–Bizkaia, SpainAs the obesity epidemic continues to grow inexorably worldwide, the need to develop effective strategies to prevent and control obesity seems crucial. The use of molecular tools can be useful to characterize different obesity phenotypes to provide more precise nutritional recommendations. This study aimed to determine the fatty acid (FA) profile of red blood cell (RBC) membranes, together with the evaluation of their dietary intake and biochemical parameters, of children and adults with obesity. An observational study was carried out on 196 children (113 with normal weight and 83 with obesity) and 91 adults (30 with normal weight and 61 with obesity). Mature RBC membrane phospholipids were analyzed for FA composition by gas chromatography-mass spectrometry (GC-MS). Dietary habits were evaluated using validated food frequency questionnaires (FFQ). Children with obesity presented higher levels of ω-6 polyunsaturated FAs (mainly linoleic acid, <i>p</i> = 0.01) and lower values of ω-3 FAs (mainly DHA, <i>p</i> < 0.001) compared with adults. Regarding blood biochemical parameters, children with obesity presented lower levels of glucose, LDL cholesterol, and alanine aminotransferase compared with adults with obesity. These lipidomic differences could be considered to provide specific nutritional recommendations for different age groups, based on an adequate fat intake.https://www.mdpi.com/2218-1989/11/1/43lipid metabolismmature erythrocyteobesityprecision nutrition |
| spellingShingle | Iker Jauregibeitia Kevin Portune Sonia Gaztambide Itxaso Rica Itziar Tueros Olaia Velasco Gema Grau Alicia Martín Luis Castaño Anna Vita Larocca Federica Di Nolfo Carla Ferreri Sara Arranz Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity Metabolites lipid metabolism mature erythrocyte obesity precision nutrition |
| title | Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity |
| title_full | Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity |
| title_fullStr | Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity |
| title_full_unstemmed | Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity |
| title_short | Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity |
| title_sort | molecular differences based on erythrocyte fatty acid profile to personalize dietary strategies between adults and children with obesity |
| topic | lipid metabolism mature erythrocyte obesity precision nutrition |
| url | https://www.mdpi.com/2218-1989/11/1/43 |
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