ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE)
The leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of stigmasterol (2). The structure of these compounds wa...
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| Format: | Article |
| Language: | English |
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Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2024-03-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
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| Online Access: | https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202401&vol=1&aid=5627 |
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| author | BASILE GOUETI WILLIAM FEUDJOU BÉNÉDICTA KPADONOU-KPOVIESSI BARDIEU ATCHADE SERONDO UWIKUNDA LÉON AHOUSSI JOACHIM GBENOU SALOMÉ KPOVIESSI |
| author_facet | BASILE GOUETI WILLIAM FEUDJOU BÉNÉDICTA KPADONOU-KPOVIESSI BARDIEU ATCHADE SERONDO UWIKUNDA LÉON AHOUSSI JOACHIM GBENOU SALOMÉ KPOVIESSI |
| author_sort | BASILE GOUETI |
| collection | DOAJ |
| description | The leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of stigmasterol (2). The structure of these compounds was determined. The Minimum Inhibitory Concentrations (MIC) for antisalmonella activity was up to 2000 µg·mL-1 for extract and fractions, and up to 500 µg·mL-1 for compound 1. The half-inhibitory Concentration (IC50) values against Plasmodium falciparum PfDd2 was 92.56 µg·mL-1 for extract and 31.24 to 77.21 µg·mL-1 for fractions. Compound 1 exhibited on the same strain an antiplasmodial activity with an IC50 value of 8.58 µg·mL-1. These results justify the use of this plant in Beninese pharmacopeia for the treatment of several diseases such as malaria. |
| first_indexed | 2024-04-24T11:53:46Z |
| format | Article |
| id | doaj.art-d981205180e746d587baf1cc0731ce73 |
| institution | Directory Open Access Journal |
| issn | 1582-540X |
| language | English |
| last_indexed | 2024-04-24T11:53:46Z |
| publishDate | 2024-03-01 |
| publisher | Alma Mater Publishing House "Vasile Alecsandri" University of Bacau |
| record_format | Article |
| series | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| spelling | doaj.art-d981205180e746d587baf1cc0731ce732024-04-09T06:42:06ZengAlma Mater Publishing House "Vasile Alecsandri" University of BacauScientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry1582-540X2024-03-01251061069ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE)BASILE GOUETI 0WILLIAM FEUDJOU 1BÉNÉDICTA KPADONOU-KPOVIESSI 2BARDIEU ATCHADE 3 SERONDO UWIKUNDA 4 LÉON AHOUSSI 5 JOACHIM GBENOU 6SALOMÉ KPOVIESSI7 University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin and Institute of Medical Research and Medicinal Plants Studies, CRPMT, P.O. Box 13033, Yaoundé, Cameroon Institute of Medical Research and Medicinal Plants Studies, CRPMT, P.O. Box 13033, Yaoundé, Cameroon University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, BeninHigher Pedagogical Institute of Bukavu, Department of Chemistry Democratic Republic of CongoUniversity of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, BeninUniversity of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, BeninUniversity of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, BeninThe leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of stigmasterol (2). The structure of these compounds was determined. The Minimum Inhibitory Concentrations (MIC) for antisalmonella activity was up to 2000 µg·mL-1 for extract and fractions, and up to 500 µg·mL-1 for compound 1. The half-inhibitory Concentration (IC50) values against Plasmodium falciparum PfDd2 was 92.56 µg·mL-1 for extract and 31.24 to 77.21 µg·mL-1 for fractions. Compound 1 exhibited on the same strain an antiplasmodial activity with an IC50 value of 8.58 µg·mL-1. These results justify the use of this plant in Beninese pharmacopeia for the treatment of several diseases such as malaria.https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202401&vol=1&aid=56271-caffeoylquinic acid lactonecolumn chromatographyethanol extractic50leavesmicspectroscopic method |
| spellingShingle | BASILE GOUETI WILLIAM FEUDJOU BÉNÉDICTA KPADONOU-KPOVIESSI BARDIEU ATCHADE SERONDO UWIKUNDA LÉON AHOUSSI JOACHIM GBENOU SALOMÉ KPOVIESSI ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry 1-caffeoylquinic acid lactone column chromatography ethanol extract ic50 leaves mic spectroscopic method |
| title | ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) |
| title_full | ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) |
| title_fullStr | ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) |
| title_full_unstemmed | ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) |
| title_short | ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE) |
| title_sort | antiplasmodial and antisalmonella activities of phenolic compound from rourea coccinea benth connaraceae |
| topic | 1-caffeoylquinic acid lactone column chromatography ethanol extract ic50 leaves mic spectroscopic method |
| url | https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202401&vol=1&aid=5627 |
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