Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis
<p>Abstract</p> <p>Background</p> <p><it>Laribacter hongkongensis </it>is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various st...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | Cell & Bioscience |
| Online Access: | http://www.cellandbioscience.com/content/1/1/17 |
| _version_ | 1811266786793881600 |
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| author | Lau Susanna KP Wong Gilman KM Tsang Alan KL Teng Jade LL Fan Rachel YY Tse Herman Yuen Kwok-Yung Woo Patrick CY |
| author_facet | Lau Susanna KP Wong Gilman KM Tsang Alan KL Teng Jade LL Fan Rachel YY Tse Herman Yuen Kwok-Yung Woo Patrick CY |
| author_sort | Lau Susanna KP |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Laribacter hongkongensis </it>is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various steps in the infective process, drug resistance and mobile genetic elements.</p> <p>Results</p> <p>For acid and bile resistance, <it>L. hongkongensis </it>possessed a urease gene cassette, two <it>arc </it>gene clusters and bile salt efflux systems. For intestinal colonization, it possessed a putative adhesin of the autotransporter family homologous to those of diffusely adherent <it>Escherichia coli </it>(<it>E. coli</it>) and enterotoxigenic <it>E. coli</it>. To evade from host defense, it possessed superoxide dismutase and catalases. For lipopolysaccharide biosynthesis, it possessed the same set of genes that encode enzymes for synthesizing lipid A, two Kdo units and heptose units as <it>E. coli</it>, but different genes for its symmetrical acylation pattern, and nine genes for polysaccharide side chains biosynthesis. It contained a number of CDSs that encode putative cell surface acting (RTX toxin and hemolysins) and intracellular cytotoxins (patatin-like proteins) and enzymes for invasion (outer membrane phospholipase A). It contained a broad variety of antibiotic resistance-related genes, including genes related to β-lactam (n = 10) and multidrug efflux (n = 54). It also contained eight prophages, 17 other phage-related CDSs and 26 CDSs for transposases.</p> <p>Conclusions</p> <p>The <it>L. hongkongensis </it>genome possessed genes for acid and bile resistance, intestinal mucosa colonization, evasion of host defense and cytotoxicity and invasion. A broad variety of antibiotic resistance or multidrug resistance genes, a high number of prophages, other phage-related CDSs and CDSs for transposases, were also identified.</p> |
| first_indexed | 2024-04-12T20:49:40Z |
| format | Article |
| id | doaj.art-d981669c00b64d9c82554ff475925520 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-12T20:49:40Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-d981669c00b64d9c82554ff4759255202022-12-22T03:17:10ZengBMCCell & Bioscience2045-37012011-04-01111710.1186/2045-3701-1-17Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysisLau Susanna KPWong Gilman KMTsang Alan KLTeng Jade LLFan Rachel YYTse HermanYuen Kwok-YungWoo Patrick CY<p>Abstract</p> <p>Background</p> <p><it>Laribacter hongkongensis </it>is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various steps in the infective process, drug resistance and mobile genetic elements.</p> <p>Results</p> <p>For acid and bile resistance, <it>L. hongkongensis </it>possessed a urease gene cassette, two <it>arc </it>gene clusters and bile salt efflux systems. For intestinal colonization, it possessed a putative adhesin of the autotransporter family homologous to those of diffusely adherent <it>Escherichia coli </it>(<it>E. coli</it>) and enterotoxigenic <it>E. coli</it>. To evade from host defense, it possessed superoxide dismutase and catalases. For lipopolysaccharide biosynthesis, it possessed the same set of genes that encode enzymes for synthesizing lipid A, two Kdo units and heptose units as <it>E. coli</it>, but different genes for its symmetrical acylation pattern, and nine genes for polysaccharide side chains biosynthesis. It contained a number of CDSs that encode putative cell surface acting (RTX toxin and hemolysins) and intracellular cytotoxins (patatin-like proteins) and enzymes for invasion (outer membrane phospholipase A). It contained a broad variety of antibiotic resistance-related genes, including genes related to β-lactam (n = 10) and multidrug efflux (n = 54). It also contained eight prophages, 17 other phage-related CDSs and 26 CDSs for transposases.</p> <p>Conclusions</p> <p>The <it>L. hongkongensis </it>genome possessed genes for acid and bile resistance, intestinal mucosa colonization, evasion of host defense and cytotoxicity and invasion. A broad variety of antibiotic resistance or multidrug resistance genes, a high number of prophages, other phage-related CDSs and CDSs for transposases, were also identified.</p>http://www.cellandbioscience.com/content/1/1/17 |
| spellingShingle | Lau Susanna KP Wong Gilman KM Tsang Alan KL Teng Jade LL Fan Rachel YY Tse Herman Yuen Kwok-Yung Woo Patrick CY Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis Cell & Bioscience |
| title | Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis |
| title_full | Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis |
| title_fullStr | Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis |
| title_full_unstemmed | Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis |
| title_short | Virulence determinants, drug resistance and mobile genetic elements of <it>Laribacter hongkongensis</it>: a genome-wide analysis |
| title_sort | virulence determinants drug resistance and mobile genetic elements of it laribacter hongkongensis it a genome wide analysis |
| url | http://www.cellandbioscience.com/content/1/1/17 |
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