E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E‐selectin binding. However, these glycoepitopes lack cancer specificity, and E‐selectin‐targeted glycoproteins remain largely unknown. Here, we established a framework for identifying metastasis‐linked...

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Detalles Bibliográficos
Autores principales: Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira
Formato: Artículo
Lenguaje:English
Publicado: Wiley 2025-03-01
Colección:Molecular Oncology
Materias:
cancer glycoproteome
colorectal cancer
E‐selectin
metastasis
secretin receptor
Acceso en línea:https://doi.org/10.1002/1878-0261.13733

Internet

https://doi.org/10.1002/1878-0261.13733

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