Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study
Abstract Constipation is a common reason for children seeking medical care worldwide. Abdominal complaints and constipation are also common in lead-poisoned children. This study evaluates the prevalence of abnormal blood lead levels (BLL) among pediatric and adolescent patients and examines the asso...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29487-y |
| _version_ | 1811165963099308032 |
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| author | Nasim Zamani Amirhossein Hosseini Fariba Farnaghi Aliakbar Sayyari Narges Gholami Farid Imanzadeh Seyed Kaveh Hadeiy Mahmoud Hajipour Amir Salimi Scott Philips Hossein Hassanian-Moghaddam |
| author_facet | Nasim Zamani Amirhossein Hosseini Fariba Farnaghi Aliakbar Sayyari Narges Gholami Farid Imanzadeh Seyed Kaveh Hadeiy Mahmoud Hajipour Amir Salimi Scott Philips Hossein Hassanian-Moghaddam |
| author_sort | Nasim Zamani |
| collection | DOAJ |
| description | Abstract Constipation is a common reason for children seeking medical care worldwide. Abdominal complaints and constipation are also common in lead-poisoned children. This study evaluates the prevalence of abnormal blood lead levels (BLL) among pediatric and adolescent patients and examines the association of constipation with elevated BLL. This was a prospective data collection of patients younger than 18 years old with the chief complaint of constipation seen in the Mofid Children’s Hospital gastroenterology clinic and Loghman Hakim pediatric and pediatric gastroenterology clinics were eligible for enrollment in this study. Constipation was defined as infrequent or difficult defecation according to ROME IV criteria lasting 2 months or more. BLL was measured with a fresh capillary whole blood capillary sample. The LeadCare II device assays BLL using an electrochemical technique (anodic stripping voltammetry). A total of 237 patients were enrolled in the study. 122 (51.48%) were female and 115 (48.52%) were male. About one fifth of patients (49; 20.67%) had BLL ≥ 5 µg/dL. The mean BLL in the sample was 3.51 µg/dL. Abdominal pain was the most common symptom accompanying constipation (134; 56%). Multivariate analysis found endoscopic evaluation (P values 0.024, OR 3.646, 95% CI 1.189–11.178), muscle pain (P values 0.020, OR 24.74, 95% CI 1.67–365.83), and maternal education (P values 0.02, OR 4.45, 95% CI 1.27–15.57) with significant differences in groups of patients with normal and elevated BLL. Elevated BLL necessitates an assessment and plans to reduce childhood lead exposure. BLL screening in childhood constipation with refractory chronic abdominal pain may also eradicate the need for invasive procedures like endoscopic evaluation. |
| first_indexed | 2024-04-10T15:44:41Z |
| format | Article |
| id | doaj.art-d98215a405614671b90656b3d1850072 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:44:41Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d98215a405614671b90656b3d18500722023-02-12T12:11:46ZengNature PortfolioScientific Reports2045-23222023-02-011311710.1038/s41598-023-29487-yBlood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional studyNasim Zamani0Amirhossein Hosseini1Fariba Farnaghi2Aliakbar Sayyari3Narges Gholami4Farid Imanzadeh5Seyed Kaveh Hadeiy6Mahmoud Hajipour7Amir Salimi8Scott Philips9Hossein Hassanian-Moghaddam10Social Determinants of Health Research Center, Shahid Beheshti University of Medical SciencesPediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical SciencesDepartment of Pediatrics, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical SciencesPediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical SciencesDepartment of Pediatrics, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical SciencesPediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesPediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesUniversity of Colorado Anschutz Medical Campus, Rocky Mountain Poison and Drug SafetySocial Determinants of Health Research Center, Shahid Beheshti University of Medical SciencesAbstract Constipation is a common reason for children seeking medical care worldwide. Abdominal complaints and constipation are also common in lead-poisoned children. This study evaluates the prevalence of abnormal blood lead levels (BLL) among pediatric and adolescent patients and examines the association of constipation with elevated BLL. This was a prospective data collection of patients younger than 18 years old with the chief complaint of constipation seen in the Mofid Children’s Hospital gastroenterology clinic and Loghman Hakim pediatric and pediatric gastroenterology clinics were eligible for enrollment in this study. Constipation was defined as infrequent or difficult defecation according to ROME IV criteria lasting 2 months or more. BLL was measured with a fresh capillary whole blood capillary sample. The LeadCare II device assays BLL using an electrochemical technique (anodic stripping voltammetry). A total of 237 patients were enrolled in the study. 122 (51.48%) were female and 115 (48.52%) were male. About one fifth of patients (49; 20.67%) had BLL ≥ 5 µg/dL. The mean BLL in the sample was 3.51 µg/dL. Abdominal pain was the most common symptom accompanying constipation (134; 56%). Multivariate analysis found endoscopic evaluation (P values 0.024, OR 3.646, 95% CI 1.189–11.178), muscle pain (P values 0.020, OR 24.74, 95% CI 1.67–365.83), and maternal education (P values 0.02, OR 4.45, 95% CI 1.27–15.57) with significant differences in groups of patients with normal and elevated BLL. Elevated BLL necessitates an assessment and plans to reduce childhood lead exposure. BLL screening in childhood constipation with refractory chronic abdominal pain may also eradicate the need for invasive procedures like endoscopic evaluation.https://doi.org/10.1038/s41598-023-29487-y |
| spellingShingle | Nasim Zamani Amirhossein Hosseini Fariba Farnaghi Aliakbar Sayyari Narges Gholami Farid Imanzadeh Seyed Kaveh Hadeiy Mahmoud Hajipour Amir Salimi Scott Philips Hossein Hassanian-Moghaddam Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study Scientific Reports |
| title | Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study |
| title_full | Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study |
| title_fullStr | Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study |
| title_full_unstemmed | Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study |
| title_short | Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study |
| title_sort | blood lead level evaluation in children presenting with chronic constipation in tehran iran a cross sectional study |
| url | https://doi.org/10.1038/s41598-023-29487-y |
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