Tumor Treating Fields: killing two birds with one stone
Given its aggressive natural history and immunosuppressive nature, glioblastoma (GBM) remains difficult to treat. Tumor Treating Fields (TTFields) are a promising treatment for GBM patients, yet the entirety of their antitumor action has not been fully elucidated. In a recent issue of the JCI, Chen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2022-04-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI159073 |
| _version_ | 1818236577132838912 |
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| author | Juyeun Lee Matthew M. Grabowski Justin D. Lathia |
| author_facet | Juyeun Lee Matthew M. Grabowski Justin D. Lathia |
| author_sort | Juyeun Lee |
| collection | DOAJ |
| description | Given its aggressive natural history and immunosuppressive nature, glioblastoma (GBM) remains difficult to treat. Tumor Treating Fields (TTFields) are a promising treatment for GBM patients, yet the entirety of their antitumor action has not been fully elucidated. In a recent issue of the JCI, Chen et al. explored the effect of TTFields in reinvigorating immune responses. By elegant step-by-step approaches, the authors demonstrated that TTFields promote the production of immune-stimulating proinflammatory and interferon type 1 cytokines in tumor cells in a cGAS/STING- and AIM2 inflammasome–dependent mechanism, thereby activating the immune system. The findings show that TTFields not only directly inhibit tumor cell growth, as previously reported, but enhance antitumor immunity, suggesting TTFields can be used as an immune-modulating approach in GBM. |
| first_indexed | 2024-12-12T12:12:04Z |
| format | Article |
| id | doaj.art-d982ba042495419ea371a5bbf58f1062 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-12-12T12:12:04Z |
| publishDate | 2022-04-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-d982ba042495419ea371a5bbf58f10622022-12-22T00:24:51ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-04-011328Tumor Treating Fields: killing two birds with one stoneJuyeun LeeMatthew M. GrabowskiJustin D. LathiaGiven its aggressive natural history and immunosuppressive nature, glioblastoma (GBM) remains difficult to treat. Tumor Treating Fields (TTFields) are a promising treatment for GBM patients, yet the entirety of their antitumor action has not been fully elucidated. In a recent issue of the JCI, Chen et al. explored the effect of TTFields in reinvigorating immune responses. By elegant step-by-step approaches, the authors demonstrated that TTFields promote the production of immune-stimulating proinflammatory and interferon type 1 cytokines in tumor cells in a cGAS/STING- and AIM2 inflammasome–dependent mechanism, thereby activating the immune system. The findings show that TTFields not only directly inhibit tumor cell growth, as previously reported, but enhance antitumor immunity, suggesting TTFields can be used as an immune-modulating approach in GBM.https://doi.org/10.1172/JCI159073 |
| spellingShingle | Juyeun Lee Matthew M. Grabowski Justin D. Lathia Tumor Treating Fields: killing two birds with one stone The Journal of Clinical Investigation |
| title | Tumor Treating Fields: killing two birds with one stone |
| title_full | Tumor Treating Fields: killing two birds with one stone |
| title_fullStr | Tumor Treating Fields: killing two birds with one stone |
| title_full_unstemmed | Tumor Treating Fields: killing two birds with one stone |
| title_short | Tumor Treating Fields: killing two birds with one stone |
| title_sort | tumor treating fields killing two birds with one stone |
| url | https://doi.org/10.1172/JCI159073 |
| work_keys_str_mv | AT juyeunlee tumortreatingfieldskillingtwobirdswithonestone AT matthewmgrabowski tumortreatingfieldskillingtwobirdswithonestone AT justindlathia tumortreatingfieldskillingtwobirdswithonestone |