Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment
Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contribu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/132 |
| _version_ | 1797495496984494080 |
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| author | Mark Samuels Chiara Cilibrasi Panagiotis Papanastasopoulos Georgios Giamas |
| author_facet | Mark Samuels Chiara Cilibrasi Panagiotis Papanastasopoulos Georgios Giamas |
| author_sort | Mark Samuels |
| collection | DOAJ |
| description | Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment. |
| first_indexed | 2024-03-10T01:50:27Z |
| format | Article |
| id | doaj.art-d9834a30221148ffbdc3f1b7f199189f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d9834a30221148ffbdc3f1b7f199189f2023-11-23T13:07:32ZengMDPI AGBiomolecules2218-273X2022-01-0112113210.3390/biom12010132Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer MicroenvironmentMark Samuels0Chiara Cilibrasi1Panagiotis Papanastasopoulos2Georgios Giamas3Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKResistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment.https://www.mdpi.com/2218-273X/12/1/132breast cancertherapy resistancetumour microenvironmentextracellular vesicles |
| spellingShingle | Mark Samuels Chiara Cilibrasi Panagiotis Papanastasopoulos Georgios Giamas Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment Biomolecules breast cancer therapy resistance tumour microenvironment extracellular vesicles |
| title | Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment |
| title_full | Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment |
| title_fullStr | Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment |
| title_full_unstemmed | Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment |
| title_short | Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment |
| title_sort | extracellular vesicles as mediators of therapy resistance in the breast cancer microenvironment |
| topic | breast cancer therapy resistance tumour microenvironment extracellular vesicles |
| url | https://www.mdpi.com/2218-273X/12/1/132 |
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