Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease
Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup> sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/1/40 |
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| author | Csaba Dienes Zsigmond Máté Kovács Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy |
| author_facet | Csaba Dienes Zsigmond Máté Kovács Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy |
| author_sort | Csaba Dienes |
| collection | DOAJ |
| description | Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup> sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regulates membrane potential and Ca<sup>2+</sup> homeostasis in both excitable and non-excitable cells. This part of the review discusses the currently available knowledge about the physiological and pathophysiological roles of TRPM4 in various tissues. These include the physiological functions of TRPM4 in the cells of the Langerhans islets of the pancreas, in various immune functions, in the regulation of vascular tone, in respiratory and other neuronal activities, in chemosensation, and in renal and cardiac physiology. TRPM4 contributes to pathological conditions such as overactive bladder, endothelial dysfunction, various types of malignant diseases and central nervous system conditions including stroke and injuries as well as in cardiac conditions such as arrhythmias, hypertrophy, and ischemia-reperfusion injuries. TRPM4 claims more and more attention and is likely to be the topic of research in the future. |
| first_indexed | 2024-03-10T00:45:33Z |
| format | Article |
| id | doaj.art-d984be5092d5443293eb315bcd557f56 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T00:45:33Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d984be5092d5443293eb315bcd557f562023-11-23T15:01:10ZengMDPI AGPharmaceuticals1424-82472021-12-011514010.3390/ph15010040Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and DiseaseCsaba Dienes0Zsigmond Máté Kovács1Tamás Hézső2János Almássy3János Magyar4Tamás Bányász5Péter P. Nánási6Balázs Horváth7Norbert Szentandrássy8Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryTransient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup> sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regulates membrane potential and Ca<sup>2+</sup> homeostasis in both excitable and non-excitable cells. This part of the review discusses the currently available knowledge about the physiological and pathophysiological roles of TRPM4 in various tissues. These include the physiological functions of TRPM4 in the cells of the Langerhans islets of the pancreas, in various immune functions, in the regulation of vascular tone, in respiratory and other neuronal activities, in chemosensation, and in renal and cardiac physiology. TRPM4 contributes to pathological conditions such as overactive bladder, endothelial dysfunction, various types of malignant diseases and central nervous system conditions including stroke and injuries as well as in cardiac conditions such as arrhythmias, hypertrophy, and ischemia-reperfusion injuries. TRPM4 claims more and more attention and is likely to be the topic of research in the future.https://www.mdpi.com/1424-8247/15/1/40TRPM4SUR1pancreatic β-cellcancerneuronalimmune system |
| spellingShingle | Csaba Dienes Zsigmond Máté Kovács Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease Pharmaceuticals TRPM4 SUR1 pancreatic β-cell cancer neuronal immune system |
| title | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease |
| title_full | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease |
| title_fullStr | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease |
| title_full_unstemmed | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease |
| title_short | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease |
| title_sort | pharmacological modulation and patho physiological roles of trpm4 channel part 2 trpm4 in health and disease |
| topic | TRPM4 SUR1 pancreatic β-cell cancer neuronal immune system |
| url | https://www.mdpi.com/1424-8247/15/1/40 |
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