Extensive accumulation of misfolded protein aggregates during natural aging and senescence

Extensive accumulation of misfolded protein aggregates during natural aging and senescence

Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, whi...

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Bibliographic Details
Main Authors: Karina Cuanalo-Contreras, Jonathan Schulz, Abhisek Mukherjee, Kyung-Won Park, Enrique Armijo, Claudio Soto
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
protein misfolding
amyloid
prions
aggresomes
senescence
proteostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1090109/full

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