Percolation transition of cooperative mutational effects in colorectal tumorigenesis
Cancer is caused by accumulating genetic mutations. Here, the authors investigate the cooperative effect of these mutations in colorectal cancer patients and identify a giant cluster of mutation-propagating modules that undergoes percolation transition during tumorigenesis.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01171-6 |
| _version_ | 1818681797331910656 |
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| author | Dongkwan Shin Jonghoon Lee Jeong-Ryeol Gong Kwang-Hyun Cho |
| author_facet | Dongkwan Shin Jonghoon Lee Jeong-Ryeol Gong Kwang-Hyun Cho |
| author_sort | Dongkwan Shin |
| collection | DOAJ |
| description | Cancer is caused by accumulating genetic mutations. Here, the authors investigate the cooperative effect of these mutations in colorectal cancer patients and identify a giant cluster of mutation-propagating modules that undergoes percolation transition during tumorigenesis. |
| first_indexed | 2024-12-17T10:08:39Z |
| format | Article |
| id | doaj.art-d984e354889242a3bfbe10c9d2f81cab |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:08:39Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d984e354889242a3bfbe10c9d2f81cab2022-12-21T21:53:07ZengNature PortfolioNature Communications2041-17232017-11-018111410.1038/s41467-017-01171-6Percolation transition of cooperative mutational effects in colorectal tumorigenesisDongkwan Shin0Jonghoon Lee1Jeong-Ryeol Gong2Kwang-Hyun Cho3Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Cancer is caused by accumulating genetic mutations. Here, the authors investigate the cooperative effect of these mutations in colorectal cancer patients and identify a giant cluster of mutation-propagating modules that undergoes percolation transition during tumorigenesis.https://doi.org/10.1038/s41467-017-01171-6 |
| spellingShingle | Dongkwan Shin Jonghoon Lee Jeong-Ryeol Gong Kwang-Hyun Cho Percolation transition of cooperative mutational effects in colorectal tumorigenesis Nature Communications |
| title | Percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| title_full | Percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| title_fullStr | Percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| title_full_unstemmed | Percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| title_short | Percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| title_sort | percolation transition of cooperative mutational effects in colorectal tumorigenesis |
| url | https://doi.org/10.1038/s41467-017-01171-6 |
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