Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway

Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway

Mitochondrial oxidative stress is involved in hair cell damage caused by noise-induced hearing loss (NIHL). Sirtuin-3 (SIRT3) plays an important role in hair cell survival by regulating mitochondrial function; however, the role of SIRT3 in NIHL is unknown. In this study, we used 3-TYP to inhibit SIR...

Full description

Bibliographic Details
Main Authors: Wenqi Liang, Chunli Zhao, Zhongrui Chen, Zijing Yang, Ke Liu, Shusheng Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SIRT3
SOD2
noise-induced hearing loss
viral transduction
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.766512/full

Similar Items

Similar Items