Late-Onset Melorheostosis: A Case Report
Melorheostosis is a rare benign bone pathology involving bone dysplasia and hyperostosis. The disease can be recognized with a characteristic radiographic feature of radiopaque lesions dripping along a long bone’s diaphysis. The aberrant bone formation and development manifests mainly as pain, edema...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-10-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://beta.karger.com/Article/FullText/534241 |
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| author | Thanh Toan Vo Kha To Thanh Nghia Dang Toan Phuc Vo Duc Thien Nguyen Duc Cong Nguyen Manh Khanh Nguyen Van Thai Nguyen |
| author_facet | Thanh Toan Vo Kha To Thanh Nghia Dang Toan Phuc Vo Duc Thien Nguyen Duc Cong Nguyen Manh Khanh Nguyen Van Thai Nguyen |
| author_sort | Thanh Toan Vo |
| collection | DOAJ |
| description | Melorheostosis is a rare benign bone pathology involving bone dysplasia and hyperostosis. The disease can be recognized with a characteristic radiographic feature of radiopaque lesions dripping along a long bone’s diaphysis. The aberrant bone formation and development manifests mainly as pain, edema, and paresthesia of the affected limb. Severe cases may report limb deformity as well as limited range of motion. Until now, there have been approximately 300 cases reported about melorheostosis worldwide and its diverse clinical picture and age distribution. In Vietnam, there is only one known case of melorheostosis discovered incidentally via radiography. The scarcity of cases presents a challenge within the medical community in recognizing and diagnosing the condition, and a delayed diagnosis can lead to severe contracture and compromised limb motility. In this article, we reported an 82-year-old case of polyostotic melorheostosis with late onset and predominant edema, affecting the sternum, the ribs, and multiple bones of the right extremities and presented our clinical approach for a geriatric patient with chronic limb edema. Our case is distinctive in terms of anatomical location as well as the predominant 20-year non-pitting edema. A prompt diagnosis was made upon the classic dripping candle wax radiographic features emphasizing the role of plain X-ray in establishing the diagnosis without extraneous utilization of other modalities and invasive procedures. Exclusion of other causes of chronic edema such as lymphadenopathy, malignancy as well as parasitic infection is of clinical importance. |
| first_indexed | 2024-03-10T04:27:12Z |
| format | Article |
| id | doaj.art-d98c2bc95c514fce9cc644ce6e6560ce |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-10T04:27:12Z |
| publishDate | 2023-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-d98c2bc95c514fce9cc644ce6e6560ce2023-11-23T07:16:29ZengKarger PublishersCase Reports in Oncology1662-65752023-10-011611237124410.1159/000534241534241Late-Onset Melorheostosis: A Case ReportThanh Toan Vo0Kha To1Thanh Nghia Dang2Toan Phuc Vo3Duc Thien Nguyen4Duc Cong Nguyen5Manh Khanh Nguyen6Van Thai Nguyen7Trauma and Orthopedics Department, Thong Nhat Hospital, Ho Chi Minh City, VietnamTrauma and Orthopedics Department, Thong Nhat Hospital, Ho Chi Minh City, VietnamSchool of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, VietnamSt. Mark’s School, Southborough, MA, USATrauma and Orthopedics Department, Thong Nhat Hospital, Ho Chi Minh City, VietnamDepartment of Geriatrics, Pham Ngoc Thach Medical University, Ho Chi Minh City, VietnamDepartment of Orthopaedics and Trauma, Vietduc University Hospital, Hanoi, VietnamDepartment of Orthopaedics and Trauma, Pham Ngoc Thach Medical University, Ho Chi Minh City, VietnamMelorheostosis is a rare benign bone pathology involving bone dysplasia and hyperostosis. The disease can be recognized with a characteristic radiographic feature of radiopaque lesions dripping along a long bone’s diaphysis. The aberrant bone formation and development manifests mainly as pain, edema, and paresthesia of the affected limb. Severe cases may report limb deformity as well as limited range of motion. Until now, there have been approximately 300 cases reported about melorheostosis worldwide and its diverse clinical picture and age distribution. In Vietnam, there is only one known case of melorheostosis discovered incidentally via radiography. The scarcity of cases presents a challenge within the medical community in recognizing and diagnosing the condition, and a delayed diagnosis can lead to severe contracture and compromised limb motility. In this article, we reported an 82-year-old case of polyostotic melorheostosis with late onset and predominant edema, affecting the sternum, the ribs, and multiple bones of the right extremities and presented our clinical approach for a geriatric patient with chronic limb edema. Our case is distinctive in terms of anatomical location as well as the predominant 20-year non-pitting edema. A prompt diagnosis was made upon the classic dripping candle wax radiographic features emphasizing the role of plain X-ray in establishing the diagnosis without extraneous utilization of other modalities and invasive procedures. Exclusion of other causes of chronic edema such as lymphadenopathy, malignancy as well as parasitic infection is of clinical importance.https://beta.karger.com/Article/FullText/534241melorheostosischronic edemadripping candle waxleri diseasehyperostosis |
| spellingShingle | Thanh Toan Vo Kha To Thanh Nghia Dang Toan Phuc Vo Duc Thien Nguyen Duc Cong Nguyen Manh Khanh Nguyen Van Thai Nguyen Late-Onset Melorheostosis: A Case Report Case Reports in Oncology melorheostosis chronic edema dripping candle wax leri disease hyperostosis |
| title | Late-Onset Melorheostosis: A Case Report |
| title_full | Late-Onset Melorheostosis: A Case Report |
| title_fullStr | Late-Onset Melorheostosis: A Case Report |
| title_full_unstemmed | Late-Onset Melorheostosis: A Case Report |
| title_short | Late-Onset Melorheostosis: A Case Report |
| title_sort | late onset melorheostosis a case report |
| topic | melorheostosis chronic edema dripping candle wax leri disease hyperostosis |
| url | https://beta.karger.com/Article/FullText/534241 |
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