Mechanisms and clinical consequences of vascular calcification
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phos...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00095/full |
| _version_ | 1811275100998074368 |
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| author | Dongxing eZhu Neil Charles Wallace Mackenzie Colin eFarquharson Vicky E Macrae |
| author_facet | Dongxing eZhu Neil Charles Wallace Mackenzie Colin eFarquharson Vicky E Macrae |
| author_sort | Dongxing eZhu |
| collection | DOAJ |
| description | Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phosphate in arteries and cardiac valves. However, recent studies have shown that vascular calcification is a highly regulated, cell-mediated process similar to bone formation. In this article, we outline the current understanding of key mechanisms governing vascular calcification and highlight the clinical consequences. By understanding better the molecular pathways and genetic circuitry responsible for the pathological mineralization process novel drug targets may be identified and exploited to combat and reduce the detrimental effects of vascular calcification on human health. |
| first_indexed | 2024-04-12T23:32:03Z |
| format | Article |
| id | doaj.art-d98edf694e6649e4b59a4eb9a57cb4c0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T23:32:03Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d98edf694e6649e4b59a4eb9a57cb4c02022-12-22T03:12:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922012-08-01310.3389/fendo.2012.0009528219Mechanisms and clinical consequences of vascular calcificationDongxing eZhu0Neil Charles Wallace Mackenzie1Colin eFarquharson2Vicky E Macrae3University of EdinburghUniversity of EdinburghUniversity of EdinburghUniversity of EdinburghVascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phosphate in arteries and cardiac valves. However, recent studies have shown that vascular calcification is a highly regulated, cell-mediated process similar to bone formation. In this article, we outline the current understanding of key mechanisms governing vascular calcification and highlight the clinical consequences. By understanding better the molecular pathways and genetic circuitry responsible for the pathological mineralization process novel drug targets may be identified and exploited to combat and reduce the detrimental effects of vascular calcification on human health.http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00095/fullVascular Calcificationtherapeutic strategiesvascular smooth muscle cellsChronic Kidney DiseaseAtheroslcerosis |
| spellingShingle | Dongxing eZhu Neil Charles Wallace Mackenzie Colin eFarquharson Vicky E Macrae Mechanisms and clinical consequences of vascular calcification Frontiers in Endocrinology Vascular Calcification therapeutic strategies vascular smooth muscle cells Chronic Kidney Disease Atheroslcerosis |
| title | Mechanisms and clinical consequences of vascular calcification |
| title_full | Mechanisms and clinical consequences of vascular calcification |
| title_fullStr | Mechanisms and clinical consequences of vascular calcification |
| title_full_unstemmed | Mechanisms and clinical consequences of vascular calcification |
| title_short | Mechanisms and clinical consequences of vascular calcification |
| title_sort | mechanisms and clinical consequences of vascular calcification |
| topic | Vascular Calcification therapeutic strategies vascular smooth muscle cells Chronic Kidney Disease Atheroslcerosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00095/full |
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