Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies
An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, <...
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| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/4/542 |
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| author | Riccardo Calvani Anna Picca Leocadio Rodriguez-Mañas Matteo Tosato Hélio José Coelho-Júnior Alessandra Biancolillo Olga Laosa Jacopo Gervasoni Aniello Primiano Lavinia Santucci Ottavia Giampaoli Isabelle Bourdel-Marchasson Sophie C. Regueme Alan J. Sinclair Andrea Urbani Francesco Landi Giovanni Gambassi Federico Marini Emanuele Marzetti |
| author_facet | Riccardo Calvani Anna Picca Leocadio Rodriguez-Mañas Matteo Tosato Hélio José Coelho-Júnior Alessandra Biancolillo Olga Laosa Jacopo Gervasoni Aniello Primiano Lavinia Santucci Ottavia Giampaoli Isabelle Bourdel-Marchasson Sophie C. Regueme Alan J. Sinclair Andrea Urbani Francesco Landi Giovanni Gambassi Federico Marini Emanuele Marzetti |
| author_sort | Riccardo Calvani |
| collection | DOAJ |
| description | An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, <i>n</i> = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, <i>n</i> = 66), and robust non-diabetic controls (<i>n</i> = 40). Partial least squares discriminant analysis (PLS–DA) models were built to define the amino acid signatures associated with the different frailty phenotypes. PLS–DA allowed correct classification of participants with 78.2 ± 1.9% accuracy. Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid. PF&S and control participants were discriminated based on serum concentrations of aminoadipic acid, aspartate, citrulline, cystine, taurine, and tryptophan. These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery. |
| first_indexed | 2024-03-11T04:46:04Z |
| format | Article |
| id | doaj.art-d98f6ec69dff4348af92d1b299b116f3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T04:46:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-d98f6ec69dff4348af92d1b299b116f32023-11-17T20:24:57ZengMDPI AGMetabolites2218-19892023-04-0113454210.3390/metabo13040542Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE StudiesRiccardo Calvani0Anna Picca1Leocadio Rodriguez-Mañas2Matteo Tosato3Hélio José Coelho-Júnior4Alessandra Biancolillo5Olga Laosa6Jacopo Gervasoni7Aniello Primiano8Lavinia Santucci9Ottavia Giampaoli10Isabelle Bourdel-Marchasson11Sophie C. Regueme12Alan J. Sinclair13Andrea Urbani14Francesco Landi15Giovanni Gambassi16Federico Marini17Emanuele Marzetti18Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyServicio de Geriatría, Hospital Universitario de Getafe, 28905 Getafe, SpainFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyDepartment of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Physical and Chemical Sciences, Università degli Studi dell’Aquila, 67100 L’Aquila, ItalyDepartment of Medicine and Surgery, LUM University, 70010 Casamassima, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyDepartment of Chemistry, Sapienza Università di Roma, 00185 Rome, ItalyClinical Gerontology Department, Bordeaux University Hospital, 33000 Bordeaux, FranceCHU Bordeaux, Pole Gérontologie Clinique, 33000 Bordeaux, FranceFoundation for Diabetes Research in Older People (fDROP), King’s College, London WC2R 2LS, UKFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyDepartment of Chemistry, Sapienza Università di Roma, 00185 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyAn altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, <i>n</i> = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, <i>n</i> = 66), and robust non-diabetic controls (<i>n</i> = 40). Partial least squares discriminant analysis (PLS–DA) models were built to define the amino acid signatures associated with the different frailty phenotypes. PLS–DA allowed correct classification of participants with 78.2 ± 1.9% accuracy. Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid. PF&S and control participants were discriminated based on serum concentrations of aminoadipic acid, aspartate, citrulline, cystine, taurine, and tryptophan. These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery.https://www.mdpi.com/2218-1989/13/4/542aginggerosciencemetabolic profilingmetabolismmetabolomicsmuscle wasting |
| spellingShingle | Riccardo Calvani Anna Picca Leocadio Rodriguez-Mañas Matteo Tosato Hélio José Coelho-Júnior Alessandra Biancolillo Olga Laosa Jacopo Gervasoni Aniello Primiano Lavinia Santucci Ottavia Giampaoli Isabelle Bourdel-Marchasson Sophie C. Regueme Alan J. Sinclair Andrea Urbani Francesco Landi Giovanni Gambassi Federico Marini Emanuele Marzetti Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies Metabolites aging geroscience metabolic profiling metabolism metabolomics muscle wasting |
| title | Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies |
| title_full | Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies |
| title_fullStr | Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies |
| title_full_unstemmed | Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies |
| title_short | Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies |
| title_sort | amino acid profiles in older adults with frailty secondary analysis from metabofrail and biosphere studies |
| topic | aging geroscience metabolic profiling metabolism metabolomics muscle wasting |
| url | https://www.mdpi.com/2218-1989/13/4/542 |
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