The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin
Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2011-08-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-70&slc_lang=en&sid=1 |
| _version_ | 1797282793287319552 |
|---|---|
| author | Júlia Niehues da Cruz Daniela Delwing de Lima Débora Delwing Dal Magro José Geraldo Pereira da Cruz |
| author_facet | Júlia Niehues da Cruz Daniela Delwing de Lima Débora Delwing Dal Magro José Geraldo Pereira da Cruz |
| author_sort | Júlia Niehues da Cruz |
| collection | DOAJ |
| description | Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo). Results: The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. Discussion: These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions. Methods: |
| first_indexed | 2024-03-07T17:18:32Z |
| format | Article |
| id | doaj.art-d9905b3482f9461a9f6c6098902045b7 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:18:32Z |
| publishDate | 2011-08-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-d9905b3482f9461a9f6c6098902045b72024-03-02T21:26:39ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-08-0124511The Power of Classic Music to Reduce Anxiety in Rats Treated with SimvastatinJúlia Niehues da Cruz0Daniela Delwing de Lima1Débora Delwing Dal Magro2José Geraldo Pereira da Cruz3 Universidade do Extremo Sul Catarinense, Santa Catarina, Brazil Universidade da Região de Joinville, Santa Catarina, Brazil Universidade Regional de Blumenau, Santa Catarina, Brazil Department of Natural Sciences, Universidade Regional de Blumenau, Santa Catarina, Brazil Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo). Results: The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. Discussion: These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions. Methods:http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-70&slc_lang=en&sid=1MusicElevated plus-mazeOpen-fieldRattus norvegicusSimvastatin. |
| spellingShingle | Júlia Niehues da Cruz Daniela Delwing de Lima Débora Delwing Dal Magro José Geraldo Pereira da Cruz The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin Basic and Clinical Neuroscience Music Elevated plus-maze Open-field Rattus norvegicus Simvastatin. |
| title | The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin |
| title_full | The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin |
| title_fullStr | The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin |
| title_full_unstemmed | The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin |
| title_short | The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin |
| title_sort | power of classic music to reduce anxiety in rats treated with simvastatin |
| topic | Music Elevated plus-maze Open-field Rattus norvegicus Simvastatin. |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-70&slc_lang=en&sid=1 |
| work_keys_str_mv | AT julianiehuesdacruz thepowerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT danieladelwingdelima thepowerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT deboradelwingdalmagro thepowerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT josegeraldopereiradacruz thepowerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT julianiehuesdacruz powerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT danieladelwingdelima powerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT deboradelwingdalmagro powerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin AT josegeraldopereiradacruz powerofclassicmusictoreduceanxietyinratstreatedwithsimvastatin |