Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)
he present paper included a study of the inhibitory effect of three pyrimidine derivatives (6-amino 1,3dimethyl uracil (6-admu), 2'-deoxythmidine (dthy) and 6-(phenylazo)-cytidine (phazocyt)) in comparison with the medical compound (6-MP) as a standard anti cancer on the inhibition of the growt...
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| Format: | Article |
| Language: | English |
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University of Anbar
2012-06-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
| Online Access: | https://juaps.uoanbar.edu.iq/article_15482_441366adc03507bccf65fa2522705f04.pdf |
| _version_ | 1797373370365378560 |
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| author | RashedM. Rashed Hammed H. Ali |
| author_facet | RashedM. Rashed Hammed H. Ali |
| author_sort | RashedM. Rashed |
| collection | DOAJ |
| description | he present paper included a study of the inhibitory effect of three pyrimidine derivatives (6-amino 1,3dimethyl uracil (6-admu), 2'-deoxythmidine (dthy) and 6-(phenylazo)-cytidine (phazocyt)) in comparison with the medical compound (6-MP) as a standard anti cancer on the inhibition of the growth of cancer cell line of Hep-2 (Human epidermoid larynx carcinoma) In vitro. Results have shown significant differences of a probability level (p<0.001), compared with 6-MP compound of (phazocyt and 6-admu), while (dthy) compound did not show any significant differences at the same level of probability (p>0.001). When comparing the inhibitory effect of concentrations within the single compound, we notice significant differences of the probability level (p<0.001), starting from the first treatment (62.5mg/ml) of (dthy) and (phazocyt) compounds. (6-admu) compound showed a significant effect in the last treatment. Result have revealed that the two compounds (dthy, phazocyt) have greater effect in comparison with 6-MP compound within (125mg/ml) concentration. Also, values of lethal inhibition concentration of (IC50) and lethal concentration of 90% of cells (IC90) were extracted. It has been found that the best activity was for (dthy) compound. |
| first_indexed | 2024-03-08T18:49:31Z |
| format | Article |
| id | doaj.art-d991773d84a847b8a8ba437275675e5a |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:49:31Z |
| publishDate | 2012-06-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-d991773d84a847b8a8ba437275675e5a2023-12-28T21:53:52ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032012-06-0131576310.37652/juaps.2009.1548215482Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)RashedM. Rashed0Hammed H. Ali1Anbar University - College of ScienceAnbar University - College of Sciencehe present paper included a study of the inhibitory effect of three pyrimidine derivatives (6-amino 1,3dimethyl uracil (6-admu), 2'-deoxythmidine (dthy) and 6-(phenylazo)-cytidine (phazocyt)) in comparison with the medical compound (6-MP) as a standard anti cancer on the inhibition of the growth of cancer cell line of Hep-2 (Human epidermoid larynx carcinoma) In vitro. Results have shown significant differences of a probability level (p<0.001), compared with 6-MP compound of (phazocyt and 6-admu), while (dthy) compound did not show any significant differences at the same level of probability (p>0.001). When comparing the inhibitory effect of concentrations within the single compound, we notice significant differences of the probability level (p<0.001), starting from the first treatment (62.5mg/ml) of (dthy) and (phazocyt) compounds. (6-admu) compound showed a significant effect in the last treatment. Result have revealed that the two compounds (dthy, phazocyt) have greater effect in comparison with 6-MP compound within (125mg/ml) concentration. Also, values of lethal inhibition concentration of (IC50) and lethal concentration of 90% of cells (IC90) were extracted. It has been found that the best activity was for (dthy) compound.https://juaps.uoanbar.edu.iq/article_15482_441366adc03507bccf65fa2522705f04.pdf |
| spellingShingle | RashedM. Rashed Hammed H. Ali Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) مجلة جامعة الانبار للعلوم الصرفة |
| title | Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) |
| title_full | Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) |
| title_fullStr | Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) |
| title_full_unstemmed | Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) |
| title_short | Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro) |
| title_sort | study of inhibition effect of three pyrimidine derivatives on growth of human epidermoid larynx carcinoma cell line hep 2 in vitro |
| url | https://juaps.uoanbar.edu.iq/article_15482_441366adc03507bccf65fa2522705f04.pdf |
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