The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia
Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organism...
Main Authors: | Robert B. Hamanaka, Samuel E. Weinberg, Colleen R. Reczek, Navdeep S. Chandel |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-04-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471630300X |
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