Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal
Phlebotomine sand fly-borne pathogens such as <i>Leishmania</i> spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess...
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MDPI AG
2019-09-01
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Online Access: | https://www.mdpi.com/2076-2607/7/9/339 |
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author | André Pereira Nazli Ayhan José Manuel Cristóvão Hugo Vilhena Ângela Martins Patrícia Cachola Joaquim Henriques Mónica Coimbra Ana Catarino Tereza Lestinova Tatiana Spitzova Petr Volf Lenea Campino Remi Charrel Carla Maia |
author_facet | André Pereira Nazli Ayhan José Manuel Cristóvão Hugo Vilhena Ângela Martins Patrícia Cachola Joaquim Henriques Mónica Coimbra Ana Catarino Tereza Lestinova Tatiana Spitzova Petr Volf Lenea Campino Remi Charrel Carla Maia |
author_sort | André Pereira |
collection | DOAJ |
description | Phlebotomine sand fly-borne pathogens such as <i>Leishmania</i> spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to <i>Phlebotomus perniciosus</i> saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, <i>n</i> = 365) were seropositive for TOSV, and eight (2.2%, <i>n</i> = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats’ health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of <i>P. perniciosus</i> to SFSV should also be addressed. |
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last_indexed | 2024-04-12T07:42:39Z |
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series | Microorganisms |
spelling | doaj.art-d992c3b91f1c4115902a5883fa4268fd2022-12-22T03:41:47ZengMDPI AGMicroorganisms2076-26072019-09-017933910.3390/microorganisms7090339microorganisms7090339Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in PortugalAndré Pereira0Nazli Ayhan1José Manuel Cristóvão2Hugo Vilhena3Ângela Martins4Patrícia Cachola5Joaquim Henriques6Mónica Coimbra7Ana Catarino8Tereza Lestinova9Tatiana Spitzova10Petr Volf11Lenea Campino12Remi Charrel13Carla Maia14Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, PortugalUnité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, FranceGlobal Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, PortugalCenter for Investigation Vasco da Gama (CIVG), Department of Veterinary Medicine, Vasco da Gama Universitary School, 3020-210 Coimbra, PortugalHospital Veterinário da Arrábida, 2925-538 Azeitão, PortugalHospital Veterinário do Algarve, 8000-072 Faro, PortugalHospital Veterinário de Berna, 1050-039 Lisboa, PortugalClínica Veterinária Porto Seguro, 8700-507 Olhão, PortugalVetCoa - Serviços Veterinários, 6320-354 Sabugal, PortugalDepartment of Parasitology, Faculty of Science, Charles University, 128 00 Prague, Czech RepublicDepartment of Parasitology, Faculty of Science, Charles University, 128 00 Prague, Czech RepublicDepartment of Parasitology, Faculty of Science, Charles University, 128 00 Prague, Czech RepublicMedical Parasitology Unit, IHMT-UNL, 1349-008 Lisboa, PortugalUnité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, FranceGlobal Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, PortugalPhlebotomine sand fly-borne pathogens such as <i>Leishmania</i> spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to <i>Phlebotomus perniciosus</i> saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, <i>n</i> = 365) were seropositive for TOSV, and eight (2.2%, <i>n</i> = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats’ health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of <i>P. perniciosus</i> to SFSV should also be addressed.https://www.mdpi.com/2076-2607/7/9/339arbovirus<i>Bunyavirales</i>cat<i>Phenuiviridae</i><i>Phlebotomus perniciosus</i><i>Phlebovirus</i>salivaSandfly Fever Sicilian VirusToscana virus |
spellingShingle | André Pereira Nazli Ayhan José Manuel Cristóvão Hugo Vilhena Ângela Martins Patrícia Cachola Joaquim Henriques Mónica Coimbra Ana Catarino Tereza Lestinova Tatiana Spitzova Petr Volf Lenea Campino Remi Charrel Carla Maia Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal Microorganisms arbovirus <i>Bunyavirales</i> cat <i>Phenuiviridae</i> <i>Phlebotomus perniciosus</i> <i>Phlebovirus</i> saliva Sandfly Fever Sicilian Virus Toscana virus |
title | Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal |
title_full | Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal |
title_fullStr | Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal |
title_full_unstemmed | Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal |
title_short | Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal |
title_sort | antibody response to toscana virus and sandfly fever sicilian virus in cats naturally exposed to phlebotomine sand fly bites in portugal |
topic | arbovirus <i>Bunyavirales</i> cat <i>Phenuiviridae</i> <i>Phlebotomus perniciosus</i> <i>Phlebovirus</i> saliva Sandfly Fever Sicilian Virus Toscana virus |
url | https://www.mdpi.com/2076-2607/7/9/339 |
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