Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection
The article presents the results of observation and treatment with ganciclovir and oral valganciclovir form of a premature infant with congenital generalized symptomatic cytomegalovirus infection (CMVI) involving pathology of CNS, cholangitis, spontaneous pathologic fracture of femoral bone. When us...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Diagnostics and Vaccines"
2016-06-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/230 |
| _version_ | 1826547071256100864 |
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| author | G. V. Petrova V. I. Shakhgildyan E. A. Chistozvonova T. A. Pugacheva N. V. Turkot M. V. Egorova O. U. Sautenko I. B. Astasheva O. V. Romanova N. V. Kostycheva T. A. Grigorieva M. G. Kulagina |
| author_facet | G. V. Petrova V. I. Shakhgildyan E. A. Chistozvonova T. A. Pugacheva N. V. Turkot M. V. Egorova O. U. Sautenko I. B. Astasheva O. V. Romanova N. V. Kostycheva T. A. Grigorieva M. G. Kulagina |
| author_sort | G. V. Petrova |
| collection | DOAJ |
| description | The article presents the results of observation and treatment with ganciclovir and oral valganciclovir form of a premature infant with congenital generalized symptomatic cytomegalovirus infection (CMVI) involving pathology of CNS, cholangitis, spontaneous pathologic fracture of femoral bone. When using ganciclovir and valganciclovir demonstrated gradual normalization of clinical and hematological parameters. In the course of treatment with ganciclovir and valganciclovir was not revealed any adverse reactions. While maintaining the CMV DNA in the blood, the duration of specific therapy, according to international recommendations, should be not less than 6 months. The decision to use a specific therapy should be made on the basis of the medical consultation, the conclusions of the medical commission and informed consent of the parents. |
| first_indexed | 2024-04-10T03:25:56Z |
| format | Article |
| id | doaj.art-d99586a6461b4d12ab6540b8aaf61de2 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2025-03-14T05:43:49Z |
| publishDate | 2016-06-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-d99586a6461b4d12ab6540b8aaf61de22025-03-05T13:50:43ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072016-06-01152616810.22627/2072-8107-2016-15-2-61-68229Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus InfectionG. V. Petrova0V. I. Shakhgildyan1E. A. Chistozvonova2T. A. Pugacheva3N. V. Turkot4M. V. Egorova5O. U. Sautenko6I. B. Astasheva7O. V. Romanova8N. V. Kostycheva9T. A. Grigorieva10M. G. Kulagina11Perinatal Medical Center, Group of Companies «Mother and Child», Moscow Moscow State University of Medicine and Dentistry, MoscowPerinatal Medical Center, Group of Companies «Mother and Child», Moscow Central Research Institute of Epidemiology of Rospotrebnadzor, MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», Moscow Pirogov Russian National Research Medical University, Moscow, RussiaPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowPerinatal Medical Center, Group of Companies «Mother and Child», MoscowMoscow State University of Medicine and Dentistry, MoscowThe article presents the results of observation and treatment with ganciclovir and oral valganciclovir form of a premature infant with congenital generalized symptomatic cytomegalovirus infection (CMVI) involving pathology of CNS, cholangitis, spontaneous pathologic fracture of femoral bone. When using ganciclovir and valganciclovir demonstrated gradual normalization of clinical and hematological parameters. In the course of treatment with ganciclovir and valganciclovir was not revealed any adverse reactions. While maintaining the CMV DNA in the blood, the duration of specific therapy, according to international recommendations, should be not less than 6 months. The decision to use a specific therapy should be made on the basis of the medical consultation, the conclusions of the medical commission and informed consent of the parents.https://detinf.elpub.ru/jour/article/view/230cytomegalovirus infectionganciclovirvalganciclovirnewborns |
| spellingShingle | G. V. Petrova V. I. Shakhgildyan E. A. Chistozvonova T. A. Pugacheva N. V. Turkot M. V. Egorova O. U. Sautenko I. B. Astasheva O. V. Romanova N. V. Kostycheva T. A. Grigorieva M. G. Kulagina Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection Детские инфекции (Москва) cytomegalovirus infection ganciclovir valganciclovir newborns |
| title | Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection |
| title_full | Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection |
| title_fullStr | Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection |
| title_full_unstemmed | Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection |
| title_short | Experience of Using the Antiviral Therapy of Generalized Congenital Cytomegalovirus Infection |
| title_sort | experience of using the antiviral therapy of generalized congenital cytomegalovirus infection |
| topic | cytomegalovirus infection ganciclovir valganciclovir newborns |
| url | https://detinf.elpub.ru/jour/article/view/230 |
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