Concerning the mechanisms of influence of redox-active nanoparticles based on rare-earth elements on the redox-processes in mitochondria
Using the kinetic computation model, which demonstrates the dependence of generation of reactive oxygen species (ROS) by complexes I and III of mitochondrion respiration chain on the values of mitochondrial potential, pH of matrix, presence of different respiratory substrates and inhibitors, and dat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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V.N. Karazin Kharkiv National University
2016-07-01
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| Series: | Біофізичний вісник |
| Subjects: | |
| Online Access: | http://periodicals.karazin.ua/biophysvisnyk/article/view/6367 |
| Summary: | Using the kinetic computation model, which demonstrates the dependence of generation of reactive oxygen species (ROS) by complexes I and III of mitochondrion respiration chain on the values of mitochondrial potential, pH of matrix, presence of different respiratory substrates and inhibitors, and data obtained experimentally, the basic mechanisms of the influence of nanoparticles (NPs) on the basis of rare earth elements on the bioenergetic processes in the mitochondria have been proposed. The mitochondrial potential, the processes of respiration and oxidative phosphorylation, as well as the ability of NPs to have an influence on the generation of ROS in the respiratory chain of mitochondria have been investigated. We propose two main mechanisms of the influence of the redox-active NPs based on the rare earth elements on the redox-processes in the mitochondria: the first mechanism involves the inhibition of electron transport and activation of the formation of superoxide and hydrogen peroxide, the second - integration of NPs into the electron-transport processes in the mitochondria as donors or acceptors of electrons |
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| ISSN: | 2075-3810 2075-3829 |