Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity

Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity

Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. Although most studies have linked CRH/CRH receptor 1 signaling to aversive, stress-like behavior, recent work has revealed a crucial role for dist...

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Bibliographic Details
Main Authors: Nina Dedic, Claudia Kühne, Karina S. Gomes, Jakob Hartmann, Kerry J. Ressler, Mathias V. Schmidt, Jan M. Deussing
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
corticotropin-releasing hormone (CRH)
stress
anxiety
resilience
GABAergic circuits
corticosterone
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00986/full

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