Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation
In order to accomplish their primary goal, mammalian spermatozoa must undergo a series of physiological, biochemical, and functional changes crucial for the acquisition of fertilization ability. Spermatozoa are highly polarized cells, which must swiftly respond to ionic changes on their passage thro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2519 |
| _version_ | 1797581129333604352 |
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| author | Filip Benko Dana Urminská Michal Ďuračka Eva Tvrdá |
| author_facet | Filip Benko Dana Urminská Michal Ďuračka Eva Tvrdá |
| author_sort | Filip Benko |
| collection | DOAJ |
| description | In order to accomplish their primary goal, mammalian spermatozoa must undergo a series of physiological, biochemical, and functional changes crucial for the acquisition of fertilization ability. Spermatozoa are highly polarized cells, which must swiftly respond to ionic changes on their passage through the female reproductive tract, and which are necessary for male gametes to acquire their functional competence. This review summarizes the current knowledge about specific ion channels and transporters located in the mammalian sperm plasma membrane, which are intricately involved in the initiation of changes within the ionic milieu of the sperm cell, leading to variations in the sperm membrane potential, membrane depolarization and hyperpolarization, changes in sperm motility and capacitation to further lead to the acrosome reaction and sperm–egg fusion. We also discuss the functionality of selected ion channels in male reproductive health and/or disease since these may become promising targets for clinical management of infertility in the future. |
| first_indexed | 2024-03-10T23:00:47Z |
| format | Article |
| id | doaj.art-d9981611ac9a40b0a5a4650c3ceed05b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:00:47Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d9981611ac9a40b0a5a4650c3ceed05b2023-11-19T09:42:29ZengMDPI AGBiomedicines2227-90592023-09-01119251910.3390/biomedicines11092519Signaling Roleplay between Ion Channels during Mammalian Sperm CapacitationFilip Benko0Dana Urminská1Michal Ďuračka2Eva Tvrdá3Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaInstitute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaAgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaInstitute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaIn order to accomplish their primary goal, mammalian spermatozoa must undergo a series of physiological, biochemical, and functional changes crucial for the acquisition of fertilization ability. Spermatozoa are highly polarized cells, which must swiftly respond to ionic changes on their passage through the female reproductive tract, and which are necessary for male gametes to acquire their functional competence. This review summarizes the current knowledge about specific ion channels and transporters located in the mammalian sperm plasma membrane, which are intricately involved in the initiation of changes within the ionic milieu of the sperm cell, leading to variations in the sperm membrane potential, membrane depolarization and hyperpolarization, changes in sperm motility and capacitation to further lead to the acrosome reaction and sperm–egg fusion. We also discuss the functionality of selected ion channels in male reproductive health and/or disease since these may become promising targets for clinical management of infertility in the future.https://www.mdpi.com/2227-9059/11/9/2519ion channelsspermatozoacapacitationhyperpolarizationacrosome reaction |
| spellingShingle | Filip Benko Dana Urminská Michal Ďuračka Eva Tvrdá Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation Biomedicines ion channels spermatozoa capacitation hyperpolarization acrosome reaction |
| title | Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation |
| title_full | Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation |
| title_fullStr | Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation |
| title_full_unstemmed | Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation |
| title_short | Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation |
| title_sort | signaling roleplay between ion channels during mammalian sperm capacitation |
| topic | ion channels spermatozoa capacitation hyperpolarization acrosome reaction |
| url | https://www.mdpi.com/2227-9059/11/9/2519 |
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