Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood. We explored the roles of deoxyribonuclease 1 (DNASE1) and deoxyribonuclease 1-like 3 (DNASE1L3) in the fragmentation of ucfDNA using mouse...

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Detalles Bibliográficos
Main Authors: Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Genetics
Acceso en liña:https://doi.org/10.1371/journal.pgen.1010262

Internet

https://doi.org/10.1371/journal.pgen.1010262

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