Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications
Diabetic wounds are a significant subset of chronic wounds characterized by elevated levels of inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They are also associated with impaired angiogenesis, persistent infection, and a high likelihood of hospitalizat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1354286/full |
| _version_ | 1797324297515040768 |
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| author | Xuewen Jiang Yu-E Zeng Chaofei Li Ke Wang Deng-Guang Yu |
| author_facet | Xuewen Jiang Yu-E Zeng Chaofei Li Ke Wang Deng-Guang Yu |
| author_sort | Xuewen Jiang |
| collection | DOAJ |
| description | Diabetic wounds are a significant subset of chronic wounds characterized by elevated levels of inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They are also associated with impaired angiogenesis, persistent infection, and a high likelihood of hospitalization, leading to a substantial economic burden for patients. In severe cases, amputation or even mortality may occur. Diabetic foot ulcers (DFUs) are a common complication of diabetes, with up to 25% of diabetic patients being at risk of developing foot ulcers over their lifetime, and more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit a structural similarity to the extracellular matrix (ECM), promoting the adhesion, growth, and migration of fibroblasts, thereby facilitating the formation of new skin tissue at the wound site. The composition and size of electrospun scaffolds can be easily adjusted, enabling controlled drug release through fiber structure modifications. The porous nature of these scaffolds facilitates gas exchange and the absorption of wound exudate. Furthermore, the fiber surface can be readily modified to impart specific functionalities, making electrospinning nanofiber scaffolds highly promising for the treatment of diabetic wounds. This article provides a concise overview of the healing process in normal wounds and the pathological mechanisms underlying diabetic wounds, including complications such as diabetic foot ulcers. It also explores the advantages of electrospinning nanofiber scaffolds in diabetic wound treatment. Additionally, it summarizes findings from various studies on the use of different types of nanofiber scaffolds for diabetic wounds and reviews methods of drug loading onto nanofiber scaffolds. These advancements broaden the horizon for effectively treating diabetic wounds. |
| first_indexed | 2024-03-08T05:54:02Z |
| format | Article |
| id | doaj.art-d998be86de14435582c376078bb79aa4 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T05:54:02Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d998be86de14435582c376078bb79aa42024-02-05T04:55:00ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13542861354286Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applicationsXuewen Jiang0Yu-E Zeng1Chaofei Li2Ke Wang3Deng-Guang Yu4School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Neurology, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaDiabetic wounds are a significant subset of chronic wounds characterized by elevated levels of inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They are also associated with impaired angiogenesis, persistent infection, and a high likelihood of hospitalization, leading to a substantial economic burden for patients. In severe cases, amputation or even mortality may occur. Diabetic foot ulcers (DFUs) are a common complication of diabetes, with up to 25% of diabetic patients being at risk of developing foot ulcers over their lifetime, and more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit a structural similarity to the extracellular matrix (ECM), promoting the adhesion, growth, and migration of fibroblasts, thereby facilitating the formation of new skin tissue at the wound site. The composition and size of electrospun scaffolds can be easily adjusted, enabling controlled drug release through fiber structure modifications. The porous nature of these scaffolds facilitates gas exchange and the absorption of wound exudate. Furthermore, the fiber surface can be readily modified to impart specific functionalities, making electrospinning nanofiber scaffolds highly promising for the treatment of diabetic wounds. This article provides a concise overview of the healing process in normal wounds and the pathological mechanisms underlying diabetic wounds, including complications such as diabetic foot ulcers. It also explores the advantages of electrospinning nanofiber scaffolds in diabetic wound treatment. Additionally, it summarizes findings from various studies on the use of different types of nanofiber scaffolds for diabetic wounds and reviews methods of drug loading onto nanofiber scaffolds. These advancements broaden the horizon for effectively treating diabetic wounds.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1354286/fullnanofiberelectrospinningwound dressingdiabetic foot ulcersnanostructures |
| spellingShingle | Xuewen Jiang Yu-E Zeng Chaofei Li Ke Wang Deng-Guang Yu Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications Frontiers in Bioengineering and Biotechnology nanofiber electrospinning wound dressing diabetic foot ulcers nanostructures |
| title | Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| title_full | Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| title_fullStr | Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| title_full_unstemmed | Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| title_short | Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| title_sort | enhancing diabetic wound healing advances in electrospun scaffolds from pathogenesis to therapeutic applications |
| topic | nanofiber electrospinning wound dressing diabetic foot ulcers nanostructures |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1354286/full |
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