Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters
The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model of exposome research. This scenario explores the fine balance between protective and exacerbating factors, providing insights into the complex relationship between...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/2/178 |
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| author | Emmanouil Karampinis Myrto-Maria Papadopoulou Kleoniki Chaidaki Konstantina-Eirini Georgopoulou Stavroula Magaliou Angeliki Viktoria Roussaki Schulze Dimitrios P. Bogdanos Efterpi Zafiriou |
| author_facet | Emmanouil Karampinis Myrto-Maria Papadopoulou Kleoniki Chaidaki Konstantina-Eirini Georgopoulou Stavroula Magaliou Angeliki Viktoria Roussaki Schulze Dimitrios P. Bogdanos Efterpi Zafiriou |
| author_sort | Emmanouil Karampinis |
| collection | DOAJ |
| description | The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model of exposome research. This scenario explores the fine balance between protective and exacerbating factors, providing insights into the complex relationship between environmental exposure and psoriasis immunopathogenesis when a trigger appears, such as that of the hyperinflammatory state induced by the COVID-19 vaccine. Analyzing interactions between vaccine-induced phenomena and exposome parameters may provide clinically relevant information important for personalized medicine decision-making. We performed a literature review seeking patients with plaque psoriasis flares or new onset or change in plaque psoriasis into another psoriasis subtype, such as pustular or erythrodermic flare, focusing on the inner and external exposome traits of patients. We identified 71 patients with plaque psoriasis flares, 12 patients with new-onset psoriasis, and 17 with plaque psoriasis subtype change, and assessed the COVID-19 vaccine-induced plaque psoriasis in terms of clinical presentation, post-vaccination flare period and treatment status, as well as inner exposome parameters (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) and external parameters (UV, infectomics). Novel data on psoriasis flares following COVID-19 vaccination are primarily obtained by combining exposome and vaccine-triggered episode features and characteristics and comparing them with similar psoriasis flares unrelated to COVID-19 vaccination. |
| first_indexed | 2024-03-07T22:11:29Z |
| format | Article |
| id | doaj.art-d99a1dd206354c7aa3ac32921774cc89 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-07T22:11:29Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d99a1dd206354c7aa3ac32921774cc892024-02-23T15:37:05ZengMDPI AGVaccines2076-393X2024-02-0112217810.3390/vaccines12020178Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome ParametersEmmanouil Karampinis0Myrto-Maria Papadopoulou1Kleoniki Chaidaki2Konstantina-Eirini Georgopoulou3Stavroula Magaliou4Angeliki Viktoria Roussaki Schulze5Dimitrios P. Bogdanos6Efterpi Zafiriou7Department of Dermatology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Internal Medicine, General Hospital of Karditsa, 43131 Karditsa, GreeceDepartment of Dermatology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Dermatology, General Hospital of Nikaia Pireus “Agios Panteleimon”—General Hospital of West Attica “Agia Varvara”, 12351 Athens, GreeceDepartment of Internal Medicine, General Hospital of Trikala, 42100 Trikala, GreeceDepartment of Dermatology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Dermatology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceThe diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model of exposome research. This scenario explores the fine balance between protective and exacerbating factors, providing insights into the complex relationship between environmental exposure and psoriasis immunopathogenesis when a trigger appears, such as that of the hyperinflammatory state induced by the COVID-19 vaccine. Analyzing interactions between vaccine-induced phenomena and exposome parameters may provide clinically relevant information important for personalized medicine decision-making. We performed a literature review seeking patients with plaque psoriasis flares or new onset or change in plaque psoriasis into another psoriasis subtype, such as pustular or erythrodermic flare, focusing on the inner and external exposome traits of patients. We identified 71 patients with plaque psoriasis flares, 12 patients with new-onset psoriasis, and 17 with plaque psoriasis subtype change, and assessed the COVID-19 vaccine-induced plaque psoriasis in terms of clinical presentation, post-vaccination flare period and treatment status, as well as inner exposome parameters (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) and external parameters (UV, infectomics). Novel data on psoriasis flares following COVID-19 vaccination are primarily obtained by combining exposome and vaccine-triggered episode features and characteristics and comparing them with similar psoriasis flares unrelated to COVID-19 vaccination.https://www.mdpi.com/2076-393X/12/2/178COVID-19vaccinationplaque psoriasisexposomeflare |
| spellingShingle | Emmanouil Karampinis Myrto-Maria Papadopoulou Kleoniki Chaidaki Konstantina-Eirini Georgopoulou Stavroula Magaliou Angeliki Viktoria Roussaki Schulze Dimitrios P. Bogdanos Efterpi Zafiriou Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters Vaccines COVID-19 vaccination plaque psoriasis exposome flare |
| title | Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters |
| title_full | Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters |
| title_fullStr | Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters |
| title_full_unstemmed | Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters |
| title_short | Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters |
| title_sort | plaque psoriasis exacerbation and covid 19 vaccination assessing the characteristics of the flare and the exposome parameters |
| topic | COVID-19 vaccination plaque psoriasis exposome flare |
| url | https://www.mdpi.com/2076-393X/12/2/178 |
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