Regulation of telomerase towards tumor therapy
Abstract Cancer is an aging-related disease, while aging plays an important role in the development process of tumor, thus the two are inextricably associated. Telomere attrition is one of the recognized hallmark events of senescence. Hence, targeting telomerase which could extends telomere sequence...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01181-6 |
| _version_ | 1797376805920833536 |
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| author | Siyu Yan Song Lin Hongxin Qiu Xining Wang Yijun He Chuanle Wang Yan Huang |
| author_facet | Siyu Yan Song Lin Hongxin Qiu Xining Wang Yijun He Chuanle Wang Yan Huang |
| author_sort | Siyu Yan |
| collection | DOAJ |
| description | Abstract Cancer is an aging-related disease, while aging plays an important role in the development process of tumor, thus the two are inextricably associated. Telomere attrition is one of the recognized hallmark events of senescence. Hence, targeting telomerase which could extends telomere sequences to treat tumors is widely favored. Cancer cells rely on high activity of telomerase to maintain a strong proliferative potential. By inhibiting the expression or protein function of telomerase, the growth of cancer cells can be significantly suppressed. In addition, the human immune system itself has a defense system against malignant tumors. However, excessive cell division results in dramatic shortening on telomeres and decline in the function of immune organs that facilitates cancer cell evasion. It has been shown that increasing telomerase activity or telomere length of these immune cells can attenuate senescence, improve cellular viability, and enhance the immunosuppressive microenvironment of tumor. In this paper, we review the telomerase-targeting progress using different anti-tumor strategies from the perspectives of cancer cells and immune cells, respectively, as well as tracking the preclinical and clinical studies of some representative drugs for the prevention or treatment of tumors. |
| first_indexed | 2024-03-08T19:43:53Z |
| format | Article |
| id | doaj.art-d99be4bfc3684a44be0d58c4cbd7699d |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-03-08T19:43:53Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-d99be4bfc3684a44be0d58c4cbd7699d2023-12-24T12:30:20ZengBMCCell & Bioscience2045-37012023-12-0113111010.1186/s13578-023-01181-6Regulation of telomerase towards tumor therapySiyu Yan0Song Lin1Hongxin Qiu2Xining Wang3Yijun He4Chuanle Wang5Yan Huang6MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging, School of Life Sciences, Sun Yat-sen UniversityAbstract Cancer is an aging-related disease, while aging plays an important role in the development process of tumor, thus the two are inextricably associated. Telomere attrition is one of the recognized hallmark events of senescence. Hence, targeting telomerase which could extends telomere sequences to treat tumors is widely favored. Cancer cells rely on high activity of telomerase to maintain a strong proliferative potential. By inhibiting the expression or protein function of telomerase, the growth of cancer cells can be significantly suppressed. In addition, the human immune system itself has a defense system against malignant tumors. However, excessive cell division results in dramatic shortening on telomeres and decline in the function of immune organs that facilitates cancer cell evasion. It has been shown that increasing telomerase activity or telomere length of these immune cells can attenuate senescence, improve cellular viability, and enhance the immunosuppressive microenvironment of tumor. In this paper, we review the telomerase-targeting progress using different anti-tumor strategies from the perspectives of cancer cells and immune cells, respectively, as well as tracking the preclinical and clinical studies of some representative drugs for the prevention or treatment of tumors.https://doi.org/10.1186/s13578-023-01181-6TelomeraseTumorImmunotherapy |
| spellingShingle | Siyu Yan Song Lin Hongxin Qiu Xining Wang Yijun He Chuanle Wang Yan Huang Regulation of telomerase towards tumor therapy Cell & Bioscience Telomerase Tumor Immunotherapy |
| title | Regulation of telomerase towards tumor therapy |
| title_full | Regulation of telomerase towards tumor therapy |
| title_fullStr | Regulation of telomerase towards tumor therapy |
| title_full_unstemmed | Regulation of telomerase towards tumor therapy |
| title_short | Regulation of telomerase towards tumor therapy |
| title_sort | regulation of telomerase towards tumor therapy |
| topic | Telomerase Tumor Immunotherapy |
| url | https://doi.org/10.1186/s13578-023-01181-6 |
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