Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

Mitoxantrone (MTX) is a drug employed in breast cancer treatment, but its application is largely limited due to side effects. A controlled delivery approach can potentially reduce the side effects. In this study, two zirconium (Zr)-based MOFs, UiO-66 and UiO-66-NH<sub>2</sub>, were studi...

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Bibliographic Details
Main Authors: Mitali Singhal, Kirsten Riches-Suman, Klaus Pors, Matthew A. Addicoat, Amalia Ruiz, Sanjit Nayak, Jacobo Elies
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Applied Sciences
Subjects:
metal–organic frameworks
breast cancer
UiO-66
UiO-66-NH<sub>2</sub>
Mitoxantrone
Online Access:https://www.mdpi.com/2076-3417/14/5/1902

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