Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)

Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)

Abstract The genus Flavivirus comprises numerous emerging and re‐emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivirus diseases. But pathogen diversities are always one of the major hindrances for timely development of new vaccines when confronting unpredic...

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Bibliographic Details
Main Authors: Ya‐Nan Zhang, Na Li, Qiu‐Yan Zhang, Jing Liu, Shun‐Li Zhan, Lei Gao, Xiang‐Yue Zeng, Fang Yu, Hong‐Qing Zhang, Xiao‐Dan Li, Cheng‐Lin Deng, Pei‐Yong Shi, Zhi‐Ming Yuan, Shao‐Peng Yuan, Han‐Qing Ye, Bo Zhang
Format: Article
Language:English
Published: Springer Nature 2021-09-01
Series:EMBO Molecular Medicine
Subjects:
flavivirus
internal poly(A)
live‐attenuated vaccine
UTR
West Nile Virus
Online Access:https://doi.org/10.15252/emmm.202114108

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