Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis
Objective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC). Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequenc...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-06-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354211021654 |
| _version_ | 1819069499422277632 |
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| author | Shao-Hua Yan MD Shuo Feng PhD Yun Xu PhD Yun-Zi Yan MD Bin He PhD Ling-Yun Sun PhD Bing Pang PhD Wen-Jia Liu MD Yu-Ying Xu MD Na Zhao MD Mo Tang MD Yue Chen MD Ming-Kun Yu MD Yu-Fei Yang PhD |
| author_facet | Shao-Hua Yan MD Shuo Feng PhD Yun Xu PhD Yun-Zi Yan MD Bin He PhD Ling-Yun Sun PhD Bing Pang PhD Wen-Jia Liu MD Yu-Ying Xu MD Na Zhao MD Mo Tang MD Yue Chen MD Ming-Kun Yu MD Yu-Fei Yang PhD |
| author_sort | Shao-Hua Yan MD |
| collection | DOAJ |
| description | Objective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC). Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequence generation were qualified. Two reviewers independently conducted the screening and data extraction. Methodological quality was assessed using the Risk of Bias tool. RevMan 5.4 was applied to the meta-analysis. Results: Twenty-seven studies involving 1867 participants were qualified, of which 26 were included in the quantitative synthesis. Meta-analysis showed that CHM significantly reduced the incidence of leukopenia induced by chemotherapy (RR = 0.69; 95% CI 0.59-0.82), as well as the grade 3/4 leukopenia (RR = 0.71; 95% CI 0.55-0.90). Meanwhile,CHM decreased the occurrence of neutropenia (RR = 0.52, 95% CI 0.35-0.77), especially for the grades 3/4 neutropenia (RR = 0.42, 95% CI 0.27-0.64). Twenty-six of the included studies focused on the adverse events related to CHM. Conclusion: CHM may relieve neutropenia/leukopenia induced by chemotherapy in adults with colorectal cancer. |
| first_indexed | 2024-12-21T16:51:01Z |
| format | Article |
| id | doaj.art-d9a0c4c0deee48aa8053dcd0337bfb9b |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-21T16:51:01Z |
| publishDate | 2021-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-d9a0c4c0deee48aa8053dcd0337bfb9b2022-12-21T18:56:53ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2021-06-012010.1177/15347354211021654Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysisShao-Hua Yan MD0Shuo Feng PhD1Yun Xu PhD2Yun-Zi Yan MD3Bin He PhD4Ling-Yun Sun PhD5Bing Pang PhD6Wen-Jia Liu MD7Yu-Ying Xu MD8Na Zhao MD9Mo Tang MD10Yue Chen MD11Ming-Kun Yu MD12Yu-Fei Yang PhD13Xiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing Institute of Traditional Chinese Medicine, Beijing, ChinaXiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaXiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaBeijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaXiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaXiyuan Hospital,China Academy of Chinese Medical Sciences, Beijing, ChinaObjective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC). Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequence generation were qualified. Two reviewers independently conducted the screening and data extraction. Methodological quality was assessed using the Risk of Bias tool. RevMan 5.4 was applied to the meta-analysis. Results: Twenty-seven studies involving 1867 participants were qualified, of which 26 were included in the quantitative synthesis. Meta-analysis showed that CHM significantly reduced the incidence of leukopenia induced by chemotherapy (RR = 0.69; 95% CI 0.59-0.82), as well as the grade 3/4 leukopenia (RR = 0.71; 95% CI 0.55-0.90). Meanwhile,CHM decreased the occurrence of neutropenia (RR = 0.52, 95% CI 0.35-0.77), especially for the grades 3/4 neutropenia (RR = 0.42, 95% CI 0.27-0.64). Twenty-six of the included studies focused on the adverse events related to CHM. Conclusion: CHM may relieve neutropenia/leukopenia induced by chemotherapy in adults with colorectal cancer.https://doi.org/10.1177/15347354211021654 |
| spellingShingle | Shao-Hua Yan MD Shuo Feng PhD Yun Xu PhD Yun-Zi Yan MD Bin He PhD Ling-Yun Sun PhD Bing Pang PhD Wen-Jia Liu MD Yu-Ying Xu MD Na Zhao MD Mo Tang MD Yue Chen MD Ming-Kun Yu MD Yu-Fei Yang PhD Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis Integrative Cancer Therapies |
| title | Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis |
| title_full | Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis |
| title_fullStr | Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis |
| title_short | Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis |
| title_sort | effectiveness of herbal medicine for leukopenia neutropenia induced by chemotherapy in adults with colorectal cancer a systematic review and meta analysis |
| url | https://doi.org/10.1177/15347354211021654 |
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