Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease
BackgroundSleep disturbances and impairment of cognitive function are among the most frequent non-motor symptoms in Parkinson’s disease (PD) with negative implications on quality of life of patients and caregivers. Despite the fact that sleep disturbances are a major issue in PD patients, only limit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00689/full |
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| author | Wiebke Hermann Wiebke Hermann Wiebke Hermann Wiebke Hermann Henning Schmitz-Peiffer Elisabeth Kasper Mareike Fauser Christiana Franke Miriam Wienecke Miriam Wienecke Karolin Otto Matthias Löhle Matthias Löhle Moritz D. Brandt Moritz D. Brandt Moritz D. Brandt Heinz Reichmann Alexander Storch Alexander Storch |
| author_facet | Wiebke Hermann Wiebke Hermann Wiebke Hermann Wiebke Hermann Henning Schmitz-Peiffer Elisabeth Kasper Mareike Fauser Christiana Franke Miriam Wienecke Miriam Wienecke Karolin Otto Matthias Löhle Matthias Löhle Moritz D. Brandt Moritz D. Brandt Moritz D. Brandt Heinz Reichmann Alexander Storch Alexander Storch |
| author_sort | Wiebke Hermann |
| collection | DOAJ |
| description | BackgroundSleep disturbances and impairment of cognitive function are among the most frequent non-motor symptoms in Parkinson’s disease (PD) with negative implications on quality of life of patients and caregivers. Despite the fact that sleep disturbances are a major issue in PD patients, only limited data are available regarding interactions of sleep disturbances and cognitive performance.ObjectiveThis post hoc analysis of the RaSPar trial was therefore designed to further elucidate sleep disturbances and their impact on cognition in PD.MethodsTwenty-six PD patients with sleep disturbances were evaluated thoroughly including assessments of patients’ subjective and objective sleep quality by interview, questionnaires, and polysomnography (PSG). Cognitive performance was assessed by Parkinson Neuropsychometric Dementia Assessment (PANDA) and Test of Attentional Performance (TAP), and associations of sleep and cognitive function were evaluated.ResultsWe did not detect differences in cognitive performance between patients with and without rapid eye movement (REM) sleep behavior disorder (RBD). Instead, cognitive impairment, particularly affecting cognitive domains attention, executive function/working memory, and semantic memory, was associated with impaired PSG-measured sleep quality (e.g., sleep efficiency) and sleep disordered breathing (SDB) (Apnea-Hypopnea Index > 5/h). Global cognitive performance was decreased in patients with SDB (PANDA score 23.2 ± 3.5 vs. 26.9 ± 2.2, P = 0.020, unpaired two-sided t-test).ConclusionSleep apnea and other sleep disturbances impair cognitive performance in PD and should be evaluated in routine care, and treatment options such as continuous airway pressure therapy should be considered. |
| first_indexed | 2024-12-20T12:49:53Z |
| format | Article |
| id | doaj.art-d9a0e638302b467abbbfad01703b341d |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T12:49:53Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d9a0e638302b467abbbfad01703b341d2022-12-21T19:40:11ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-08-011410.3389/fnins.2020.00689509411Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s DiseaseWiebke Hermann0Wiebke Hermann1Wiebke Hermann2Wiebke Hermann3Henning Schmitz-Peiffer4Elisabeth Kasper5Mareike Fauser6Christiana Franke7Miriam Wienecke8Miriam Wienecke9Karolin Otto10Matthias Löhle11Matthias Löhle12Moritz D. Brandt13Moritz D. Brandt14Moritz D. Brandt15Heinz Reichmann16Alexander Storch17Alexander Storch18Department of Neurology, Technische Universität Dresden, Dresden, GermanySleep Centre, Department of Neurology and Department of Internal Medicine, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Research Site Rostock, Rostock, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanySleep Centre, Department of Neurology and Department of Internal Medicine, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Research Site Rostock, Rostock, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanySleep Centre, Department of Neurology and Department of Internal Medicine, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Research Site Dresden, Dresden, GermanyDepartment of Neurology, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, University of Rostock, Rostock, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Research Site Rostock, Rostock, GermanyBackgroundSleep disturbances and impairment of cognitive function are among the most frequent non-motor symptoms in Parkinson’s disease (PD) with negative implications on quality of life of patients and caregivers. Despite the fact that sleep disturbances are a major issue in PD patients, only limited data are available regarding interactions of sleep disturbances and cognitive performance.ObjectiveThis post hoc analysis of the RaSPar trial was therefore designed to further elucidate sleep disturbances and their impact on cognition in PD.MethodsTwenty-six PD patients with sleep disturbances were evaluated thoroughly including assessments of patients’ subjective and objective sleep quality by interview, questionnaires, and polysomnography (PSG). Cognitive performance was assessed by Parkinson Neuropsychometric Dementia Assessment (PANDA) and Test of Attentional Performance (TAP), and associations of sleep and cognitive function were evaluated.ResultsWe did not detect differences in cognitive performance between patients with and without rapid eye movement (REM) sleep behavior disorder (RBD). Instead, cognitive impairment, particularly affecting cognitive domains attention, executive function/working memory, and semantic memory, was associated with impaired PSG-measured sleep quality (e.g., sleep efficiency) and sleep disordered breathing (SDB) (Apnea-Hypopnea Index > 5/h). Global cognitive performance was decreased in patients with SDB (PANDA score 23.2 ± 3.5 vs. 26.9 ± 2.2, P = 0.020, unpaired two-sided t-test).ConclusionSleep apnea and other sleep disturbances impair cognitive performance in PD and should be evaluated in routine care, and treatment options such as continuous airway pressure therapy should be considered.https://www.frontiersin.org/article/10.3389/fnins.2020.00689/fullParkinson’s diseasesleep disorderssleep disordered breathingsleep apneacognitioncognitive performance |
| spellingShingle | Wiebke Hermann Wiebke Hermann Wiebke Hermann Wiebke Hermann Henning Schmitz-Peiffer Elisabeth Kasper Mareike Fauser Christiana Franke Miriam Wienecke Miriam Wienecke Karolin Otto Matthias Löhle Matthias Löhle Moritz D. Brandt Moritz D. Brandt Moritz D. Brandt Heinz Reichmann Alexander Storch Alexander Storch Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease Frontiers in Neuroscience Parkinson’s disease sleep disorders sleep disordered breathing sleep apnea cognition cognitive performance |
| title | Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease |
| title_full | Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease |
| title_fullStr | Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease |
| title_full_unstemmed | Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease |
| title_short | Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease |
| title_sort | sleep disturbances and sleep disordered breathing impair cognitive performance in parkinson s disease |
| topic | Parkinson’s disease sleep disorders sleep disordered breathing sleep apnea cognition cognitive performance |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00689/full |
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