Women with epilepsy and infertility have different reproductive hormone profile than others
Purpose: One-third of women with epilepsy (WWE) may experience infertility (failure to conceive after 12 months of regular unprotected intercourse). We aimed to compare the hormone profile of WWE and infertility (WWE-I) with that of WWE who had conceived earlier (WWE-F). Materials and Methods: In th...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=544;epage=548;aulast=Thomas |
| _version_ | 1818528538828996608 |
|---|---|
| author | Sanjeev V Thomas P S Sarma C Nirmala Annamma Mathai Sara E Thomas Asha C Thomas |
| author_facet | Sanjeev V Thomas P S Sarma C Nirmala Annamma Mathai Sara E Thomas Asha C Thomas |
| author_sort | Sanjeev V Thomas |
| collection | DOAJ |
| description | Purpose: One-third of women with epilepsy (WWE) may experience infertility (failure to conceive after 12 months of regular unprotected intercourse). We aimed to compare the hormone profile of WWE and infertility (WWE-I) with that of WWE who had conceived earlier (WWE-F). Materials and Methods: In the Kerala Registry of Epilepsy and Pregnancy, we compared the clinical and hormone profile of 50 WWE-I and 40 age-matched WWE-F. Subjects were examined and blood samples were drawn in follicular phase (1-14 days) for 21 WWE-I and 18 WWE-F, in luteal phase (15-30 days) for 23 WWE-I and 15 WWE-F and beyond 30 days for 6 WWE-I and WWE-F who had irregular cycles. Results: The two groups were comparable regarding physical, epilepsy syndrome, duration of epilepsy, body mass index, and serum cholesterol levels. Menstrual periods were irregular for 6 WWE-I and 5 WWE-F. The WWE-I group (compared to the WWE-F group) had significantly (P < 0.01) higher levels of dehydroepiandrostenedione (2.0 ± 1.7 ug/mL vs. 1.0 ± 0.7 ug/mL) and luteinizing hormone-LH (26.4 ± 37.3 mIU/mL vs. 9.9 ± 14.5 mIU/mL) and lower levels of progesterone (5.2 ± 9.2 ng/mL vs. 10.4 ± 13.4 ng/mL). There was no significant difference in the levels of FT3, FT4, thyroid stimulating hormone, prolactin, follicle-stimulating hormone (FSH), progesterone, testosterone, or androstenedione levels. The WWE-I had 8.5 times higher risk (95% confidence interval 1.2-59.9) of abnormal LH/FSH ratio. WWE who were on antiepileptic drugs (AEDs) (compared to WWE who were not on AEDs) had higher risk of elevated LH/FSH ratio. Conclusion: The hormone profile of WWE-I is significantly different from that of WWE-F. These variations need to be interpreted with caution as a causal relationship to epilepsy or use of antiepileptic drugs need to be established through further studies. |
| first_indexed | 2024-12-11T06:51:14Z |
| format | Article |
| id | doaj.art-d9a1d76c3e694938a16ee330aae2976c |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-11T06:51:14Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-d9a1d76c3e694938a16ee330aae2976c2022-12-22T01:16:55ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492013-01-0116454454810.4103/0972-2327.120460Women with epilepsy and infertility have different reproductive hormone profile than othersSanjeev V ThomasP S SarmaC NirmalaAnnamma MathaiSara E ThomasAsha C ThomasPurpose: One-third of women with epilepsy (WWE) may experience infertility (failure to conceive after 12 months of regular unprotected intercourse). We aimed to compare the hormone profile of WWE and infertility (WWE-I) with that of WWE who had conceived earlier (WWE-F). Materials and Methods: In the Kerala Registry of Epilepsy and Pregnancy, we compared the clinical and hormone profile of 50 WWE-I and 40 age-matched WWE-F. Subjects were examined and blood samples were drawn in follicular phase (1-14 days) for 21 WWE-I and 18 WWE-F, in luteal phase (15-30 days) for 23 WWE-I and 15 WWE-F and beyond 30 days for 6 WWE-I and WWE-F who had irregular cycles. Results: The two groups were comparable regarding physical, epilepsy syndrome, duration of epilepsy, body mass index, and serum cholesterol levels. Menstrual periods were irregular for 6 WWE-I and 5 WWE-F. The WWE-I group (compared to the WWE-F group) had significantly (P < 0.01) higher levels of dehydroepiandrostenedione (2.0 ± 1.7 ug/mL vs. 1.0 ± 0.7 ug/mL) and luteinizing hormone-LH (26.4 ± 37.3 mIU/mL vs. 9.9 ± 14.5 mIU/mL) and lower levels of progesterone (5.2 ± 9.2 ng/mL vs. 10.4 ± 13.4 ng/mL). There was no significant difference in the levels of FT3, FT4, thyroid stimulating hormone, prolactin, follicle-stimulating hormone (FSH), progesterone, testosterone, or androstenedione levels. The WWE-I had 8.5 times higher risk (95% confidence interval 1.2-59.9) of abnormal LH/FSH ratio. WWE who were on antiepileptic drugs (AEDs) (compared to WWE who were not on AEDs) had higher risk of elevated LH/FSH ratio. Conclusion: The hormone profile of WWE-I is significantly different from that of WWE-F. These variations need to be interpreted with caution as a causal relationship to epilepsy or use of antiepileptic drugs need to be established through further studies.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=544;epage=548;aulast=ThomasAntiepileptic druginfertilitypregnancyreproductive endocrine |
| spellingShingle | Sanjeev V Thomas P S Sarma C Nirmala Annamma Mathai Sara E Thomas Asha C Thomas Women with epilepsy and infertility have different reproductive hormone profile than others Annals of Indian Academy of Neurology Antiepileptic drug infertility pregnancy reproductive endocrine |
| title | Women with epilepsy and infertility have different reproductive hormone profile than others |
| title_full | Women with epilepsy and infertility have different reproductive hormone profile than others |
| title_fullStr | Women with epilepsy and infertility have different reproductive hormone profile than others |
| title_full_unstemmed | Women with epilepsy and infertility have different reproductive hormone profile than others |
| title_short | Women with epilepsy and infertility have different reproductive hormone profile than others |
| title_sort | women with epilepsy and infertility have different reproductive hormone profile than others |
| topic | Antiepileptic drug infertility pregnancy reproductive endocrine |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=544;epage=548;aulast=Thomas |
| work_keys_str_mv | AT sanjeevvthomas womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers AT pssarma womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers AT cnirmala womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers AT annammamathai womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers AT saraethomas womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers AT ashacthomas womenwithepilepsyandinfertilityhavedifferentreproductivehormoneprofilethanothers |