Radiation-induced sarcomas: A single referral cancer center experience and literature review
Background and objectiveThe oncogenic effect of ionizing radiation is widely known. Sarcomas developing after radiation therapy (RT), termed “iatrogenic disease of success”, represent a growing problem, since the advancements in cancer management and screening programs have increased the number of l...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.986123/full |
| _version_ | 1818016179410698240 |
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| author | Simona Laurino Ludmila Carmen Omer Francesco Albano Graziella Marino Antonella Bianculli Angela Pia Solazzo Alessandro Sgambato Geppino Falco Sabino Russi Anna Maria Bochicchio |
| author_facet | Simona Laurino Ludmila Carmen Omer Francesco Albano Graziella Marino Antonella Bianculli Angela Pia Solazzo Alessandro Sgambato Geppino Falco Sabino Russi Anna Maria Bochicchio |
| author_sort | Simona Laurino |
| collection | DOAJ |
| description | Background and objectiveThe oncogenic effect of ionizing radiation is widely known. Sarcomas developing after radiation therapy (RT), termed “iatrogenic disease of success”, represent a growing problem, since the advancements in cancer management and screening programs have increased the number of long-term cancer survivors. Although many patients have been treated with radiation therapy, only few data are available on radiation-induced sarcomas (RIS).MethodsWe examined the medical and radiological records of 186 patients with histologically proven soft tissue and bone sarcomas, which referred to IRCCS CROB Centro di Riferimento Oncologico della Basilicata from January 2009 to May 2022. Among them, seven patients received a histological diagnosis of secondary RIS, according to Cahan’s criteria. Clinicopathological features and treatment follow-up data of RIS patients were retrospectively analyzed.ResultsAmong these secondary RIS, five arose in irradiated breast cancer (5/2,570, 0.19%) and two in irradiated head and neck cancer (2/1,986, 0.10%) patients, with a mean onset latency time of 7.3 years. The histology of RIS was one desmoid tumor, two angiosarcomas, one chondrosarcoma, two leiomyosarcomas, and one undifferentiated pleomorphic sarcoma. Out of the seven RIS, one received radiotherapy, one received electrochemotherapy (ECT), one received a second-line chemotherapy, three were subjected to three lines of chemotherapy, and one underwent radiofrequency ablation, chemotherapy, and ECT. Median survival time is 36 months. No significant survival differences were found stratifying patients for age at RT, latency time, and age at RIS diagnosis.ConclusionsRIS represents a possible complication for long-survivor cancer patients. Therefore, adherence to a strict follow-up after the radiation treatment is recommended to allow early diagnosis and optimal management of RIS patients. After the planned follow-up period, considering the long-term risk to develop a RIS, a specific multispecialty survivorship care plan could be of benefit for patients. |
| first_indexed | 2024-04-14T07:09:40Z |
| format | Article |
| id | doaj.art-d9a358e31b1141f19e427e86eed7e7e2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T07:09:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d9a358e31b1141f19e427e86eed7e7e22022-12-22T02:06:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.986123986123Radiation-induced sarcomas: A single referral cancer center experience and literature reviewSimona Laurino0Ludmila Carmen Omer1Francesco Albano2Graziella Marino3Antonella Bianculli4Angela Pia Solazzo5Alessandro Sgambato6Geppino Falco7Sabino Russi8Anna Maria Bochicchio9Laboratory of Preclinical and Translational Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyTrial Office, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyDepartment of Breast Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyRadiotherapy Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyRadiotherapy Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyDepartment of Biology, University of Naples Federico II, Naples, ItalyLaboratory of Preclinical and Translational Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyMultispecialty Tumor Board, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, ItalyBackground and objectiveThe oncogenic effect of ionizing radiation is widely known. Sarcomas developing after radiation therapy (RT), termed “iatrogenic disease of success”, represent a growing problem, since the advancements in cancer management and screening programs have increased the number of long-term cancer survivors. Although many patients have been treated with radiation therapy, only few data are available on radiation-induced sarcomas (RIS).MethodsWe examined the medical and radiological records of 186 patients with histologically proven soft tissue and bone sarcomas, which referred to IRCCS CROB Centro di Riferimento Oncologico della Basilicata from January 2009 to May 2022. Among them, seven patients received a histological diagnosis of secondary RIS, according to Cahan’s criteria. Clinicopathological features and treatment follow-up data of RIS patients were retrospectively analyzed.ResultsAmong these secondary RIS, five arose in irradiated breast cancer (5/2,570, 0.19%) and two in irradiated head and neck cancer (2/1,986, 0.10%) patients, with a mean onset latency time of 7.3 years. The histology of RIS was one desmoid tumor, two angiosarcomas, one chondrosarcoma, two leiomyosarcomas, and one undifferentiated pleomorphic sarcoma. Out of the seven RIS, one received radiotherapy, one received electrochemotherapy (ECT), one received a second-line chemotherapy, three were subjected to three lines of chemotherapy, and one underwent radiofrequency ablation, chemotherapy, and ECT. Median survival time is 36 months. No significant survival differences were found stratifying patients for age at RT, latency time, and age at RIS diagnosis.ConclusionsRIS represents a possible complication for long-survivor cancer patients. Therefore, adherence to a strict follow-up after the radiation treatment is recommended to allow early diagnosis and optimal management of RIS patients. After the planned follow-up period, considering the long-term risk to develop a RIS, a specific multispecialty survivorship care plan could be of benefit for patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.986123/fullbreast cancerhead and neck cancerradiation-induced sarcomaradiotherapylong-term radiation effects |
| spellingShingle | Simona Laurino Ludmila Carmen Omer Francesco Albano Graziella Marino Antonella Bianculli Angela Pia Solazzo Alessandro Sgambato Geppino Falco Sabino Russi Anna Maria Bochicchio Radiation-induced sarcomas: A single referral cancer center experience and literature review Frontiers in Oncology breast cancer head and neck cancer radiation-induced sarcoma radiotherapy long-term radiation effects |
| title | Radiation-induced sarcomas: A single referral cancer center experience and literature review |
| title_full | Radiation-induced sarcomas: A single referral cancer center experience and literature review |
| title_fullStr | Radiation-induced sarcomas: A single referral cancer center experience and literature review |
| title_full_unstemmed | Radiation-induced sarcomas: A single referral cancer center experience and literature review |
| title_short | Radiation-induced sarcomas: A single referral cancer center experience and literature review |
| title_sort | radiation induced sarcomas a single referral cancer center experience and literature review |
| topic | breast cancer head and neck cancer radiation-induced sarcoma radiotherapy long-term radiation effects |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.986123/full |
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