The genotype‐phenotype landscape of an allosteric protein

The genotype‐phenotype landscape of an allosteric protein

Abstract Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Yet a quantitative understanding of allosteric genotype‐phenotype relationships remains elusive. Here, we report the large‐scale measurement of the genotype‐phenotype landscape for a...

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Bibliographic Details
Main Authors: Drew S Tack, Peter D Tonner, Abe Pressman, Nathan D Olson, Sasha F Levy, Eugenia F Romantseva, Nina Alperovich, Olga Vasilyeva, David Ross
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:Molecular Systems Biology
Subjects:
allostery
genetic sensor
genotype‐phenotype relationships
high‐throughput measurements
transcription factor
Online Access:https://doi.org/10.15252/msb.202010179

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