GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model

GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model

Abstract Background and aims The accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER) stress, which is a critical consequence in human disorders such as familial hypercholesterolemia, cardiovascular and hepatic diseases. In addition...

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Bibliographic Details
Main Authors: Divya Saro Varghese, Deepu Oommen, Anne John, Bassam R. Ali
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Lipids in Health and Disease
Subjects:
ER stress
oxLDL
ER stress sensors
Hepatotoxicity
Apoptosis
Online Access:https://doi.org/10.1186/s12944-023-01835-x

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