Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer
Summary: In this study, we explore the dynamic process of colorectal cancer progression, emphasizing the evolution toward a more metastatic phenotype. The term “evolution” as used in this study specifically denotes the phenotypic transition toward a higher metastatic potency from well-formed glandul...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724002407 |
| _version_ | 1797271421565534208 |
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| author | Soon Sang Park Young-Kyoung Lee Yong Won Choi Su Bin Lim So Hyun Park Han Ki Kim Jun Sang Shin Young Hwa Kim Dong Hyun Lee Jang-Hee Kim Tae Jun Park |
| author_facet | Soon Sang Park Young-Kyoung Lee Yong Won Choi Su Bin Lim So Hyun Park Han Ki Kim Jun Sang Shin Young Hwa Kim Dong Hyun Lee Jang-Hee Kim Tae Jun Park |
| author_sort | Soon Sang Park |
| collection | DOAJ |
| description | Summary: In this study, we explore the dynamic process of colorectal cancer progression, emphasizing the evolution toward a more metastatic phenotype. The term “evolution” as used in this study specifically denotes the phenotypic transition toward a higher metastatic potency from well-formed glandular structures to collective invasion, ultimately resulting in the development of cancer cell buddings at the invasive front. Our findings highlight the spatial correlation of this evolution with tumor cell senescence, revealing distinct types of senescent tumor cells (types I and II) that play different roles in the overall cancer progression. Type I senescent tumor cells (p16INK4A+/CXCL12+/LAMC2−/MMP7−) are identified in the collective invasion region, whereas type II senescent tumor cells (p16INK4A+/CXCL12+/LAMC2+/MMP7+), representing the final evolved form, are prominently located in the partial-EMT region. Importantly, type II senescent tumor cells associate with local invasion and lymph node metastasis in colorectal cancer, potentially affecting patient prognosis. |
| first_indexed | 2024-03-07T14:02:28Z |
| format | Article |
| id | doaj.art-d9a77409dd0543b58b26f3fa817bd04e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T14:02:28Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-d9a77409dd0543b58b26f3fa817bd04e2024-03-07T05:27:26ZengElsevierCell Reports2211-12472024-03-01433113912Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancerSoon Sang Park0Young-Kyoung Lee1Yong Won Choi2Su Bin Lim3So Hyun Park4Han Ki Kim5Jun Sang Shin6Young Hwa Kim7Dong Hyun Lee8Jang-Hee Kim9Tae Jun Park10Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, KoreaDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, KoreaInflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea; Department of Hematology and Oncology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, KoreaInflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea; Department of Pathology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea; Department of Brain Science and Neurology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Surgery, Ajou University School of Medicine, Suwon 16499, KoreaInflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea; Department of Pathology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, KoreaInflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea; Department of Pathology, Ajou University School of Medicine, Suwon 16499, Korea; Corresponding authorDepartment of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea; Corresponding authorSummary: In this study, we explore the dynamic process of colorectal cancer progression, emphasizing the evolution toward a more metastatic phenotype. The term “evolution” as used in this study specifically denotes the phenotypic transition toward a higher metastatic potency from well-formed glandular structures to collective invasion, ultimately resulting in the development of cancer cell buddings at the invasive front. Our findings highlight the spatial correlation of this evolution with tumor cell senescence, revealing distinct types of senescent tumor cells (types I and II) that play different roles in the overall cancer progression. Type I senescent tumor cells (p16INK4A+/CXCL12+/LAMC2−/MMP7−) are identified in the collective invasion region, whereas type II senescent tumor cells (p16INK4A+/CXCL12+/LAMC2+/MMP7+), representing the final evolved form, are prominently located in the partial-EMT region. Importantly, type II senescent tumor cells associate with local invasion and lymph node metastasis in colorectal cancer, potentially affecting patient prognosis.http://www.sciencedirect.com/science/article/pii/S2211124724002407CP: Cancer |
| spellingShingle | Soon Sang Park Young-Kyoung Lee Yong Won Choi Su Bin Lim So Hyun Park Han Ki Kim Jun Sang Shin Young Hwa Kim Dong Hyun Lee Jang-Hee Kim Tae Jun Park Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer Cell Reports CP: Cancer |
| title | Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| title_full | Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| title_fullStr | Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| title_full_unstemmed | Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| title_short | Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| title_sort | cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer |
| topic | CP: Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724002407 |
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